Syntheses of 1-(3-oxoalkyl)indole-2-3-diones

Synthesis and structure of new oxoindoles

“…3-(2-Aryl-2-oxoethylidene)-2-indolinones and products of their heterocyclization, which have a variety of physiological activities are of especial interest [6][7][8][9][10][11][12][13][14]. With the objectives of broadening the range of compounds in the oxoindole series with potential biological activity and in continuing our study of synthetic reactions of indoline-2,3-dione (1) [15][16][17][18] we have investigated suitable routes for its conversion into 1-alkylindoline-2,3-diones 2-7 and compounds 8-13. We have previously reported [9] that 3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one (8) was obtained from the condensation of isatin with acetophenone in dry EtOH.…”