Syntheses of azepinoindole alkaloids cimitrypazepine, fargesine and hyrtioreticulins C & D

Abstract

Syntheses of azepinoindole alkaloids cimitrypazepine, fargesine and hyrtioreticulins C & D Ganesh Ghimire The Watanabe-Cenini-Söderberg reductive N-heterocyclization has emerged as a powerful tool for the synthesis of a variety of functionalized indoles. Söderberg's elaboration of this methodology has been utilized as a late-stage cyclization protocol for the synthesis of azepinoindole alkaloids, a class of natural products characterized by an azepane skeleton fused with an indole ring. Short syntheses of the naturally occurring azepino[5,4,3-cd]indole alkaloids, cimitrypazepine, fargesine, and the diastereomeric hyrtioreticulins C & D have been completed starting from commercially available tetra-substituted benzene derivatives. The key azepinoindole core in each case was assembled via an intramolecular Mizoroki-Heck reaction followed by a Watanabe-Cenini-Söderberg reductive N-heterocyclization. Synthesis of aurantioclavine using a similar strategy is currently underway.

Facial Expression Recognition using Facial Landmark Detection and Feature Extraction via Neural Networks

“…This was done after extracting facial landmark features and then using a PCA-LDA hybrid approach for dimensionality reduction and performance improvement. For hybrid methods, some approaches [6] have combined geometric and appearance features to complement the positive outcomes of each other and in fact, achieve better results in certain cases. In video sequences, many systems [2,7,8] are used to measure the geometrical displacement of facial landmarks between the current frame and previous frame as temporal features.…”