2024
DOI: 10.1039/d4ob00777h
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Syntheses of deuterium-labeled dihydroartemisinic acid (DHAA) isotopologues and mechanistic studies focused on elucidating the conversion of DHAA to artemisinin

Kaitlyn Varela,
Francis K. Yoshimoto

Abstract: Dihydroartemisinic acid (DHAA) is the sesquiterpenoid natural product from Artemisia annua, which converts to artemisinin through the incorporation of two molecules of oxygen in a four-step sequence. The reaction is...

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