Syntheses of deuterium-labeled dihydroartemisinic acid (DHAA) isotopologues and mechanistic studies focused on elucidating the conversion of DHAA to artemisinin
Kaitlyn Varela,
Francis K. Yoshimoto
Abstract:Dihydroartemisinic acid (DHAA) is the sesquiterpenoid natural product from Artemisia annua, which converts to artemisinin through the incorporation of two molecules of oxygen in a four-step sequence. The reaction is...
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