1989
DOI: 10.1016/s0040-4039(01)80643-2
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Syntheses of enantiomers of 2-[6-(4-chlorophenoxy)hexyl]-oxirane-2-carboxylic acid

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Cited by 11 publications
(2 citation statements)
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“…[1‐ 14 C]palmitic acid was from Amersham (Little Chalfont, UK). Etomoxir was synthesized by Professor B. Golding in the School of Natural Sciences, University of Newcastle upon Tyne, according to the method of Crilley et al . (1989) with modifications as described by Scott & Golding (2004).…”
Section: Methodsmentioning
confidence: 99%
“…[1‐ 14 C]palmitic acid was from Amersham (Little Chalfont, UK). Etomoxir was synthesized by Professor B. Golding in the School of Natural Sciences, University of Newcastle upon Tyne, according to the method of Crilley et al . (1989) with modifications as described by Scott & Golding (2004).…”
Section: Methodsmentioning
confidence: 99%
“…15 Sharpless epoxidation has been reported before in the synthesis of Etomoxir 3a, but the synthesis of the necessary precursor 7 was long and inconvenient. 16 Our synthesis of precursor 7 is just two steps, and the complete synthesis of 4-Chlorophenol 5 was alkylated with an excess of 1,5-dibromopentane, sodium hydroxide and a phase-transfer catalyst to give the bromide 6 in a slightly modified literature procedure. 17 This was used to alkylate methallyl alcohol, doubly deprotonated with butyl lithium in the presence of TMEDA.…”
Section: Introductionmentioning
confidence: 99%