Syntheses of Isocinchomeronic Monoesters

Nuclear magnetic resonance studies on pyridine dinucleotides. II. Solution conformational dynamics of nicotinamide adenine dinucleotide and nicotinamide mononucleotide as viewed by proton T1 measurements

“…The 'H Ti's were determined in two different solutions: one with phosphate buffer and one without any added buffer. The relaxation rates for the buffered solutions indicate that, within experimental error, the correlation time, rc, has increased by approximately 30 ± 10% in going from pD 7 to 2. Whereas, in the solutions where the buffer was absent, the observed change in…”

Characterization and Insulin‐Mimetic Potential of Oxidovanadium(IV) Complexes Derived from Monoesters and ‐carboxylates of 2,5‐Dipicolinic Acid

“…Products were dried at room temperature under vacuum and stored under N 2 . The following compounds were prepared according to published procedures: 6-(methoxycarbonyl)-pyridine-3-carboxylic acid (1), [9] methyl 5-(chlorocarbonyl)pyridine-2-carboxylate, [10] myo-inositol-orthoformate, [11,12] 1,2:3,4-di-O-isopropylidene-α--galactose, [13] [VO(pic) 2 ], [14] K[VO 2 (pic) 2 ], [14] K[VO 2 (2,5dipic)]. [15] Analyses and Methods: Elemental analyses were carried out in the Analytical Laboratory of the Chemistry Department, University of Hamburg.…”

General methods of synthesis of indole alkaloids. 14. Short routes of construction of yohimboid and ajmalicinoid alkaloid systems and their carbon-13 nuclear magnetic resonance spectral analysis

“…After much experimentation exact reaction conditions for the addition of dimethyl malonate to salts la, 6a, and 6b and subsequent cyclization of compounds 7 were found, thus permitting the preparation of tetracycles 8d, 8e, and 8f. Not only was the first reaction difficult especially in view of its reversibility, but this tendency of fragmentation of 7 into the pyridine salt precursors plagued also the second reaction. 13 The stereochemistry of compounds 8a and 8f was elucidated by l3C NMR spectroscopy and diester 8f served as an excellent intermediate in the synthesis of a variety of admalicinoid alkaloids (vide infra).…”