Syntheses of naphthyl-based quaternary ammonium surfactants and their catalytic properties in chloromethylation of naphthalene

Qian, Feng; Zhou, Haijun

doi:10.1016/j.molliq.2020.112557

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…However, the uncharged 1,1′-binaphthyl ( 3 ; Supplementary Fig. 6b ) had extremely low solubility in aqueous buffer and naphthyl-based quaternary amines (which would be the most likely candidates for testing positively charged naphthalene derivatives) have been shown to form micelles 44 . Thus, these features precluded meaningful measurements with both types of compounds.…”

Section: Resultsmentioning

confidence: 99%

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

et al. 2020

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Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in the cell. However, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregation and disease. Accordingly, there is great interest in identifying small molecules that modulate LLPS. Here, we demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of protein LLPS. Depending on context, bis-ANS can both induce LLPS de novo as well as prevent formation of homotypic liquid droplets. Our study also reveals the mechanisms by which bis-ANS and related compounds modulate LLPS and identify key chemical features of small molecules required for this activity. These findings may provide a foundation for the rational design of small molecule modulators of LLPS with therapeutic value.

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Section: Resultsmentioning

confidence: 99%