Syntheses of β-Lactams

Benzotriazole-mediated amidoalkylations of nitroalkanes, nitriles, alkynes and esters

“…44 Therefore, a number of synthetic pathways have been devised for their preparation including (Scheme 7), (i) enantioselective hydrogenations of β-amine acrylate; 45 (ii) asymmetric additions of different enolate equivalents to imines; 46 and (iii) reactions of N-(α-aminoalkyl)benzotriazoles with ketene silyl acetals catalyzed by either lanthanide triflate 47 or methyl lithium. 48 We now report that reaction of esters with 1 provides a novel access to β-(Nprotected-amino)alkyl esters 13 (Scheme 8).…”

Green Synthesis of 1‐(1,2,4‐Triazol‐4‐yl)spiro[azetidine‐2,3′‐(3H)indole]‐2′,4′(1′H)‐diones as Potential Insecticidal Agents

“…A recent example of this is Pfizer's fluconazole, the Schiff's base with isatin, which exhibits antimicrobial activity . β‐Lactams (azetidinones) are the key components of many biologically active compounds such as penicillin and cephalosporin antibiotics and show antibacterial , antifungal , and anti‐inflammatory activities. These are also used to inhibit cholesterol absorption .…”

Des 6H-thiazines-1,3 aux céphèmes par cyclocondensation

“…Toutefois, peu de travaux concement les 6H-thiazines-1,3 substituCes en positions 2, 4 et 5. Dans certains cas, lorsque la position 2 des 6H-thiazines-1,3 2 est substituCe par un groupement aromatique, il n'a pas CtC possible d'obtenir le ctphkme correspondant (5).…”