Syntheses, structural characterization and biological activities of spiro-ansa-spiro-cyclotriphosphazenes

Abstract

spiro-ansa-spiro-Phosphazenes were investigated for their DNA binding, antimicrobial activities and cytotoxic, apoptotic, and necrotic effects on fibroblast and lung cancer cells.

The Syntheses and Structural Characterizations, Antimicrobial Activity and in Vitro Dna Binding of 4-Fluorobenzylspiro(n/O)cyclotriphosphazenes and Their Phosphazenium Salts

“…Some of the cyclotriphosphazene derivatives are used as liquid crystals [7,8], rechargeable lithium-ion batteries [9,10], OLEDs [11,12], and lubricants [13,14]. It is found that aminocyclophosphazene derivatives have antimicrobial activity against bacteria and fungi [15][16][17]. The interactions between DNA and the phosphazene derivatives have also been investigated in the two last decades [18,19].…”

Phosphorus-nitrogen compounds- (Part 50): correlations between structuralparameters for cylophosphazene derivatives containing ferrocenyl pendant arm(s)

“…Because of their tendency to react with the nucleophilic mono-, di-, or multi-functional groups [3][4][5][6], both of the cyclophosphazenes were used in the syntheses of a considerable range of organocyclotri/tetraphosphazene derivatives with diverse applications [7,8]. The substantial efforts have been performed on the nucleophilic substitution reactions, in which the 1-to 6-Cl-atoms on trimer and 1-to 8-Cl atoms on tetramer have been replaced by the NH and/or OH functioned reagents, forming isomeric products e.g., structural (spiro-, ansa-and bino-architectures or a mixed of the same or different architectures), geometrical (geminal, non-geminal cis/trans-), and optical isomers [9,10]. The nature of the products strongly depends on the various chemical factors which control the replacement reaction mechanisms such as chain lengths of nucleophilic groups, the polarity of solvents, and the reaction temperature [11].…”

Phosphorus-nitrogen compounds (Part 51): the relationship betweenspectroscopic and crystallographic data of mono- and di-spirocyclophosphazenederivatives with 4-fluoro/nitrophenylmethyl pendant arm/arms

“…In recent years, cyclotri and cyclotetraphosphazenes have started to attract much attention due to their potential stereogenic properties, and biological activities such as antibacterial, antifungal and anti-cancer activities [8][9][10][11][12]. Our group has spent many years on designating and synthesizing novel partly substituted cyclotri and cyclotetraphosphazene derivatives with bidentate ligands {dibenzo-diaza-crown ethers [13][14][15][16][17], dibenzo N 2 O n (n =2-4) [18][19][20][21] and benzo NO [22][23][24][25][26][27][28] donor * Correspondence: sbilge@science.ankara.edu.tr type aminopodands, mono-and bis-ferrocenyldiamines [29][30][31][32][33][34][35][36][37], sodium (ferrocenylmethylamino)-1-alkoxide [38][39][40][41][42][43]}and multidentate N 2 O 2 -donor type dibenzo aminopodands [44][45][46]. Some interesting phosphazene derivatives such as monotopic and ditopic spiro-crypta phosphazenes, spirocyclic phosphaza (PNP-lariat) ethers, cyclophosphazenes possessing 6-membered spiro ring/rings, mono and bisferrocenylspirocyclophosphazenes, and spiro-ansa-spiro-, spiro-bino-spiro-and ansa-spiro-ansa-phosphazenes were synthesized.…”