Synthesis, 99mTc-radiolabeling and in vivo evaluation of a new sulphonamide derivative for solid tumor imaging

Shamsel-Din, Hesham A.; Zaki, E. G.

doi:10.1007/s10967-020-07317-z

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Along with alkaline (NaOH), two novel types of surfactants synthesized from sulfonamide derivatives were evaluated as EOR agents through measuring the interfacial tension and applying flooding tests on both core and sandpack systems, where the sulfonamide agent has shown great success in the medical field, as it is used in the treatment and diagnosis of cancer and it is cheap and easy to synthesize. 66 A set of flooding experiments were performed to evaluate the effect of the selected chemical formulations on oil recovery. The potential of the flooding solutions to alter the wettability of rock was studied through using relative permeability saturation curves, 67 while the oil displacement efficiency was determined through the fractional flow curves.…”

Section: Introductionmentioning

confidence: 99%

“…This study aims to evaluate the potential of alkaline/surfactant flooding on oil recovery performance. Along with alkaline (NaOH), two novel types of surfactants synthesized from sulfonamide derivatives were evaluated as EOR agents through measuring the interfacial tension and applying flooding tests on both core and sandpack systems, where the sulfonamide agent has shown great success in the medical field, as it is used in the treatment and diagnosis of cancer and it is cheap and easy to synthesize . A set of flooding experiments were performed to evaluate the effect of the selected chemical formulations on oil recovery.…”

Section: Introductionmentioning

confidence: 99%

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Sulfonamide Derivatives as Novel Surfactant/Alkaline Flooding Processes for Improving Oil Recovery

Soliman,

ElSahaa,

Elsaeed

et al. 2023

ACS Omega

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Over time, oil consumption has increased along with a continuous demand for petroleum products that require finding ways to increase hydrocarbon production more economically and effectively. So, enhanced oil recovery technologies are believed to be very promising and will serve as a key to meeting the future energy demand. This paper aims to introduce an innovative method to boost the EOR by using two novel types of surfactants synthesized from sulfonamide derivatives. Types I and II surfactants were analyzed using Fourier transform infrared spectroscopy, and their characterization was further performed using 1H NMR and 13C NMR spectroscopy. Additionally, the evaluation of these surfactants included interfacial tension measurements at concentrations up to 0.9 wt %. The combination of types I and II surfactants with alkaline (NaOH) was also investigated by the measurements of interfacial tension. A series of coreflood and sandpack tests under high-salinity conditions were carried out to assess the effects of a surfactant alone and alkaline–surfactant as a combination on improving oil recovery. The rock wettability was evaluated using relative permeability saturation curves, and the oil displacement efficiency was determined using fractional flow curves. The coreflood results demonstrated that alkaline–surfactant flooding with the chemical formula 0.2 wt % surfactant type II plus 0.5 wt % NaOH achieved a higher oil recovery of 74% OOIP compared to surfactant flooding with the chemical formula 0.5 wt % surfactant type II (64% OOIP) and waterflooding (saline solution with a 35,000 ppm salinity: 48% OOIP). Moreover, the experimental results showed that under both core and sandpack flood conditions, there was a noticeable reduction in oil–water interfacial tension, a change in rock wettability to more water-wet, and higher efficiency of oil displacement when alkaline was added to the surfactant. Based on current research, the alkaline–surfactant formulation is strongly recommended for chemical flooding because of its high efficacy and relatively low cost.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sulfonamide Derivatives as Novel Surfactant/Alkaline Flooding Processes for Improving Oil Recovery

Soliman,

ElSahaa,

Elsaeed

et al. 2023

ACS Omega

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“…In this work we used a template that has abroad applicability, more familiar, and more economical material. We used a sulfonamide derivative EPBS [25]…”

Section: Introductionmentioning

confidence: 99%

New Template in Synthesis of Copper Tungsten -Mesoporous Silica for Photo Oxidative-Desulfurization of Dibenzothiophene

Salem

Mohmed²,

Zaki³

2022

Preprint

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A novel CuWO4/SiO2 heterojunction catalyst was successfully synthesized using a new sulfonamide derivative. The physical characteristics of the prepared samples were investigated by TGA, XRD, FTIR, SEM, UV, PL, and XPS. The prepared catalysts were applied as a nano photocatalyst for photooxidative desulfurization of dibenzothiophene under visible light using hydrogen peroxide as an oxidant. The photocatalytic oxidative desulfurization performances of the prepared samples were investigated. Various factors as the reaction time, dibenzothiophene concentration, catalyst dose, and the oxidizing agent dose were also studied. The prepared photocatalyst has high desulfurization activity in the removal of DBT under mild conditions. Results showed that the CuWO4/SiO2 exhibited considerably higher activity than neat support SiO2. Such improved photocatalytic activity is mainly attributed to the efficient separation of photogenerated electron-hole pairs on CuWO4/SiO2 heterojunction. Moreover, the synergistic effects of this photocatalytic oxidation and the green oxidant hydrogen peroxide played an essential role in desulfurization. The reaction is pseudo-first-order and can reach 98.6 % removal of dibenzothiophene after 70 min and 97.2% after four cycles.

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Microwave-assisted synthesis and 99mTc-radiolabeling of anti-inflammatory active curcumin derivatives for inflammation diagnosis and therapy

Shamsel-Din,

Gizawy,

Attaallah

et al. 2024

J Radioanal Nucl Chem

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Using a one-pot cyclo-condensation process under microwave irradiation, derivatives of curcumin have been created. Evaluation their anti-inflammatory efficacy showed that they had stronger properties than curcumin. Additionally, the most active derivative was radiolabeled with the diagnostic radioisotope technetium-99m and prepared with a high radiochemical yield (96.5 ± 0.09%) and in vitro stability of up to 6 h. The in-vivo study in inflamed mice showed that [99mTc]Tc-curcumin derivative accumulated with a high target to non-target ratio. The gathered information confirmed the efficacy of the [99mTc]Tc-curcumin derivative as a novel possible tracer for the identification and localization of inflammation.

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Synthesis, 99mTc-radiolabeling and in vivo evaluation of a new sulphonamide derivative for solid tumor imaging

Cited by 4 publications

References 35 publications

Sulfonamide Derivatives as Novel Surfactant/Alkaline Flooding Processes for Improving Oil Recovery

Sulfonamide Derivatives as Novel Surfactant/Alkaline Flooding Processes for Improving Oil Recovery

New Template in Synthesis of Copper Tungsten -Mesoporous Silica for Photo Oxidative-Desulfurization of Dibenzothiophene

Microwave-assisted synthesis and 99mTc-radiolabeling of anti-inflammatory active curcumin derivatives for inflammation diagnosis and therapy

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