Synthesis &amp; characterization of amino acid-based acrylamide derived amphiphilic block copolymer using a new xanthate and its influence on cell cytotoxicity &amp; cell viability

Afgan, Shere; Pal, Krishtan; Srivastava, Arti; Nandy, Koushik; Yadav, Paramjeet; Jaiswal, Sheetal; Singh, Rajan; Singh, Rakesh; Kumar, Rajesh

doi:10.1016/j.eurpolymj.2023.111853

Cited by 7 publications

(1 citation statement)

References 57 publications

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“…A copper tube with λ value of 1.5418 Å and a 2θ range of 10 -80 against intensity was used to examine the samples using the scanning speed 2 /min (Figure 5). 25 F I G U R E 1 Photographic images of the formation of hydrogels.…”

Section: Determination Of Glass Transition Temperature (Dsc)mentioning

confidence: 99%

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Yadav,

Afgan,

Pal

et al. 2024

Journal of Polymer Science

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Hydrogel‐based materials represent promising candidates for drug delivery. In our research, we synthesized a series of hydrogels—PVATU‐1 (2:1), PVATU‐2 (1:1), and PVATU‐3 (0.5:1)—by adjusting the poly(vinyl alcohol) (PVA) ratio while maintaining a constant ratio of allylthiourea (ATU) monomer and glutaraldehyde cross‐linker, aiming to understand their impacts on gelation. These PVATU hydrogels displayed impressive swelling in neutral conditions and exhibited visible self‐healing capabilities. Notably, PVATU‐1 shows superior mechanical strength among the variants. Surface analysis using AFM and SEM unveiled porous structures within the hydrogels, while thermal stability tests indicated their resilience up to 200°C. DSC analysis revealed minimal variation in glass transition temperatures (Tg), affirming stability. A distinct endothermic peak around 250–350°C across all hydrogels confirmed their semi‐crystalline nature, corroborated by powder XRD. Noteworthy, PVATU‐1 demonstrated optimal loading and releasing efficiency for levofloxacin, with 74.5% loading and 82.8% releasing efficiency within 18 h. Biocompatibility assessments on HeLa cells affirmed the nontoxicity of PVATU hydrogel treatments.

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Section: Determination Of Glass Transition Temperature (Dsc)mentioning

confidence: 99%

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Yadav,

Afgan,

Pal

et al. 2024

Journal of Polymer Science

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Chitosan‐based self‐healing hydrogel mediated by poly(acrylic‐methacrylic acid) exhibiting high biocompatibility and anti‐tumor activity

Pal,

Kumar,

Yadav

et al. 2024

J of Applied Polymer Sci

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Multi‐responsive, self‐healing hydrogels were developed utilizing positively charged polysaccharides, chitosan, and water‐soluble chitosan. This fabrication employed free‐radical synthesized polyacrylic acid and polymethacrylic acid along with the cross‐linker FeCl3, resulting in the generation of polyelectrolyte metal complexes, which enhances the properties of the chitosan‐based hydrogels, particularly their mechanical strength, self‐healing ability, thermal stability, swelling behavior, porous structure, cell viability, and even anticancer activity. Characterization and stability assessment of the hydrogels were performed using FT‐IR, nuclear magnetic resonance, gel permeation chromatography, scanning electron microscopy, rheometer, x‐ray diffraction, thermogravimetric analysis, DSC, and UV spectroscopy. FT‐IR measurements indicated that the facile complexation of the cross‐linker's metal ions (Fe3+) with the carboxylate (COO−), amino (NH), and hydroxyl (OH) groups of the polymers and chitosan chains facilitated rapid gelation. Furthermore, the sustained release of the drug levofloxacin (up to 80%) was observed to increase with increasing pH due to the hydrogels' anionic nature. Biocompatibility and cytotoxicity tests were conducted using the MTT assay on splenocytes and Dalton Lymphoma cancer cell lines. These tests demonstrated the promising potential of these hydrogels for drug delivery applications.

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PVA/AMPS hydrogels: Promising adsorbents for wastewater treatment with high efficiency and reusability

Yadav,

Afgan,

Singh

et al. 2024

J of Applied Polymer Sci

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A PVAMPS hydrogel was synthesized through chemical cross‐linking and semi‐interpenetration of Poly (vinyl Alcohol) (PVA) and 2‐Acrylamido‐2‐methyl‐1‐propanesulfonic acid (AMPS) with glutaraldehyde in distilled water. Various ratios of PVA/AMPS, namely PVAMPS‐1 (2:1), PVAMPS‐2 (1:1), and PVAMPS‐3 (1:2), were examined to understand their individual impacts on gel formation. The synthesis of hydrogels was confirmed using FT‐IR and solid‐state 13C NMR spectroscopy. The PVAMPS hydrogels demonstrated high efficiency as a selective adsorbent for removing cationic dyes, such as Methylene Blue, Safranine‐O, and Thionine, from aqueous solutions, with over 90% removal of cationic dyes observed within 18 hours. Regeneration and reusability studies revealed that even after four cycles, the adsorption capacity of the PVAMPS hydrogels remained exceptionally high, with removal rates exceeding 90% for Methylene Blue. However, for Safranine‐O and Thionine, the removal rates dropped to 20% and 23%, respectively, after four cycles. These findings underscore the promising potential of PVAMPS hydrogels for the removal of cationic dyes in wastewater treatment.

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Synthesis & characterization of amino acid-based acrylamide derived amphiphilic block copolymer using a new xanthate and its influence on cell cytotoxicity & cell viability

Cited by 7 publications

References 57 publications

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Allylthiourea‐mediated self‐healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

Chitosan‐based self‐healing hydrogel mediated by poly(acrylic‐methacrylic acid) exhibiting high biocompatibility and anti‐tumor activity

PVA/AMPS hydrogels: Promising adsorbents for wastewater treatment with high efficiency and reusability

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