Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives

“…- [1,2,4]triazino [5,6-b]indole (24) A mixture of 5H- [1,2,4]triazino [5,6-b] indole-3-thiol (22, 0.01 mol) [71] and hydrazine hydrate (10 mL, 98%) was heated on water bath for 5 h. The product was collected, washed with ethanol and dried. It was recrystallized from ethanol.…”

“…Many pyrazole derivatives are reported to have a broad spectrum of biological activities, such as anti-inflammatory [13], antifungal [14], antiviral [15], cytotoxic [12], A3 adenosine receptor antagonists [16], antioxidant [13], antihypertensive [17], tranquilizing, muscle relaxant, psychoanaleptic, hypnotic, ulcerogenic, antidepressant, antibacterial and analgesic effects [18]. Pharmacologically-interesting heterocyclic systems like pyrazolines have been widely studied owing to their pharmacological activities, which include anti-tumor [19,20], anti-inflammatory [21][22][23][24][25][26][27][28][29][30][31][32], anti-parasitary [33], anticonvulsant [34], antimicrobial [35][36][37][38][39], antinociceptives [40], antimalarial [41], nitric oxide synthase inhibitory, associated with diseases such as Alzheimer, Huntington, and inflammatory arthritis [42], antidepressant [43,44], anticancer [45][46][47], antibacterial [48], antitubercular, analgesic [49], antiviral [46], antioxidant [50], antiamoebic …”

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“…R. S. Joshi et al 44 investigated a series of morpholine bearing pyrazolines(2q) as analgesic and antiinflammatory agent and revealed that some compounds showed good analgesic and antiinflammatory inhibition almost equivalent to the standard.…”

Synthesis of Some Chalcones and Pyrazolines Carrying Morpholinophenyl Moiety as Potential Anti‐Inflammatory Agents

“…It is pertinent to mention that 4-phenylmorpholine derivatives have been reported to show anti-inflammatory [24,25] and antimicrobial [26,27] activities.…”