Synthesis, Analgesic, and Antiparkinsonian Profiles of Some Pyridine, Pyrazoline, and Thiopyrimidine Derivatives

Chemical, structural and biological studies of cis-[Pt(3-Acpy)2Cl2]

“…Similarly, 3-acetylpyridine acts as a precursor in the synthesis of some analgesics and as a cofactor for depleting detoxification inside the cells [19,20]. In addition, there are several structures in the literature where this molecule functions as a ligand attached to 3d and 4f metals of different architectures [21].…”

Molecular Docking Study of Newly Synthesized Thiopyrimidines as Antimicrobial Agents Targeting DNA Gyrase Enzyme

“…Pyrimidines, being an integral component of nucleic acid, play an important role in several biological processes. They are used as building blocks in pharmaceutics for the synthesis of nucleoside antibiotics, antiviral, antibacterial, and antifungal agents . Various pyrimidine derivatives showed anticancer, cardiovascular, antiarrhythmic, antiparkinsonian, anti‐inflammatory, and analgesic activities .…”

A rapid access to novel and diverse 3-oxothiazolo[3,2- $$c$$ c ]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions

“…Also, thiazolo[3,2-a]pyrimidines can be considered as another important derivative of thiazolopyrimidines. Both types exhibit a variety of biological properties, such as antitumor and cytotoxic [3], immunomodulatory [4], antimicrobial [5,6], antipsychotic [7], antiinflammatory [8,9,17], calcium antagonist [10], antiviral [11], antiparkinsonian [12], antiarrhythmic [13], antidepressant [14], anticancer [15,18], and analgesic [16] activities ( Fig. 1).…”