“…14 ) were chosen as candidates for extensive greenhouse bioassays on larvae and eggs of T. cinnabarinus. Both of them showed potency consistent with pyriminostrobin against larvae and weaker potency than pyriminostrobin against eggs, as shown in Table 50 [ 59 ]. Fig.…”
Section: Biological Significance Of Pyrimidine Scaffoldsmentioning
Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. The present review article aims to review the work reported on therapeutic potentials of pyrimidine scaffolds which are valuable for medical applications during new generation.
“…14 ) were chosen as candidates for extensive greenhouse bioassays on larvae and eggs of T. cinnabarinus. Both of them showed potency consistent with pyriminostrobin against larvae and weaker potency than pyriminostrobin against eggs, as shown in Table 50 [ 59 ]. Fig.…”
Section: Biological Significance Of Pyrimidine Scaffoldsmentioning
Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. The present review article aims to review the work reported on therapeutic potentials of pyrimidine scaffolds which are valuable for medical applications during new generation.
“…Pyrimidine is an important class of heterocyclic compounds with wide applications in medicine and pesticides research due to their remarkable biological and pharmacological properties, such as antibacterial [23][24][25], antiviral [26,27], insecticide [28,29], anticancer [30,31], antimalaria [32], herbicida [33] and other biological activities [34]. In 2019, Zhang reported a series of derivatives containing pyrimidine ethers were synthesized, which have a good control effect on cucumber downy mildew [35].…”
A series of pyrimidine-containing 4H-chromen-4-one derivatives were designed and synthesized by combining bioactive substructures. All compounds were characterized using 1 H NMR, 13 C NMR, 19 F NMR and HRMS. Preliminary biological activity results showed that most of title compounds displayed signi cant inhibitory activity against Xanthomonas axonopodis pv. Citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo) and Ralstonia solanacearum (Rs). In particular, compound 4c demonstrated a good inhibitory effect against Xac and Xoo, with half-maximal effective concentration(EC 50 ) values of 15.5 and 14.9 μg/mL respectively, and that of compound 4h showed the best antibacterial activity against Rs with an EC 50 value of 14.7 μg/mL, These results were better than both bismerthiazol (BT, 51.7, 70.1 and 52.7 μg/mL, respectively) and thiodiazole copper (TC, 77.9, 95.8 and 72.1 μg/mL respectively). In vivo antibacterial activity results indicated that compound 4c displayed better curative(42.4%) and protective (49.2%) activities for reducing rice bacterial leaf blight than both BT (35.2, 39.1%) and TC (30.8, 27.3%). The mechanism of compound 4c against Xoo was analysed through scanning electron microscopy (SEM). Results showed that the compound destroied the bacterial cell membrane structure. These results indicated that pyrimidine-containing 4H-chromen-4-one derivatives are valuable in the research of new agrochemicals.
“…Pyrimidine derivatives are well known for their pharmacological activities, including antiviral, 1 anticancer, 2 − 4 anti-inflammatory, 5 acaricidal, 6 insecticidal, 7 herbicidal, 8 herbicide safener, 9 and even fungicidal activities. 10 − 12 Commonly used commercial pyrimidine fungicides include diflumetorim ( Figure 1 a), pyrimethanil ( Figure 1 b), and azoxystrobin ( Figure 1 c).…”
Section: Introductionmentioning
confidence: 99%
“…Pyrimidine derivatives are well known for their pharmacological activities, including antiviral, anticancer, − anti-inflammatory, acaricidal, insecticidal, herbicidal, herbicide safener, and even fungicidal activities. − Commonly used commercial pyrimidine fungicides include diflumetorim (Figure a), pyrimethanil (Figure b), and azoxystrobin (Figure c). These molecules can be employed for efficient control over plant pathogenic fungi, such as ascomycetes, basidiomycetes, and deuteromycetes, often found in vegetables, fruits, and grain crops. ,− However, the widespread application of some commercial pyrimidine fungicide agents led to the development of resistance. − For example, the destructive plant pathogen Phytophthora capsici has developed great resistance to azoxystrobin in southern China .…”
Fenclorim is a commercial
herbicide safener with fungicidal activity
used for chloroacetanilide herbicides, which might be suitable as
a lead compound for screening novel fungicides. However, little has
been reported so far on the structure–activity relationship
of fungicidal activities of fenclorim or its analogues. Here, a series
of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was
synthesized by a substructure splicing route using fenclorim as a
lead compound. The structures of synthesized derivatives were characterized
by
1
H NMR,
13
C NMR, and HRMS. Their fungicidal
and herbicide safening activities were then evaluated. The results
revealed that compound
11
had the best fungicidal activity
against
Sclerotinia sclerotiorum
and
Thanatephorus cucumeris
, which was better than that
of the control pyrimethanil. Moreover, compounds
3
,
5
, and
25
exhibited excellent safening activities
against fresh weight, plant height, and root length, respectively.
Such activities were significantly improved when compared to fenclorim.
In summary, these findings look promising for the preparation of new
fungicides and herbicide safeners based on the structure of fenclorim.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
