Synthesis and acaricidal activity of 3‐aryl‐5‐arylmethyl‐1, 3,4‐oxa(thia)diazol‐2(3h)‐ones

Abstract

A series of new 1,3, 4‐oxa(thia)diazol‐2(3H)‐ones were synthesized and tested as acaricides. High activities against eggs of Tetranychus urticae (Koch) were found for derivatives bearing an ortho‐halo‐substituted phenyl group in position 3, and a benzyl group para‐substituted by a branched C3‐C6 alkoxy group in position 5 of the hetero‐ring. The best compounds attained the miticidal potency of clofentezine.

Chemoenzymic Synthesis of Optically Pure 1,3,4-Oxadiazol-2(3H)-ones with Acaricidal Activity

“…Recently, a new series of 3-aryl-5-(arylalkyl)-l,3,4oxa(thia)diazol-2(3ii)-ones with miticidal activity has been reported (Bettarini et al, 1994). Within this class, (R,S)-3-(2-chlorophenyl)-5-[l-[(4-isopropoxy)phenyl]ethyl]l,3,4-oxadiazol-2(3if)-one (la) turned out to be one of the most active compounds (Figure 1).…”

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“…They have been found to in¯uence CNS [1], effect tyrosinase inhibition [2] and some of them show bacteriostatic [3], antitubercular [4], anti-in¯ammatory [5], and pesticidal activity [6,7]. They have been found to in¯uence CNS [1], effect tyrosinase inhibition [2] and some of them show bacteriostatic [3], antitubercular [4], anti-in¯ammatory [5], and pesticidal activity [6,7].…”