1977
DOI: 10.1073/pnas.74.4.1610
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Synthesis and activation of mitotic Ca2+-adenosinetriphosphatase during the cell cycle of mouse mastocytoma cells.

Abstract: The activity of a Ca2+-adenosinetriphosphatase (ATP phosphohydrolase, EC 3.6.1.3) increases during the mitotic phase of synchronized mouse mastocytoma P-815X2 cells. The enzyme is synthesized mainly during a distinct period of the interphase and is activated at mitosis. It is thought to regulate the formation of the mitotic apparatus by controlling the concentration of Ca2+ ions at the site of formation of the mitotic spindle.Ca2+ ions have been implicated as regulating factors in mitosis (1). They can interfe… Show more

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Cited by 20 publications
(8 citation statements)
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“…A Ca2+-sensitive ATPase has also been shown to be associated with the mitotic apparatus (25). The activity of this enzyme peaks during mitosis in many cell types (26,27). Moreover, the Ca2+-ATPase activity bas been identified with the smooth endoplasmic reticulum of mitotic cells (28 …”
Section: Discussionmentioning
confidence: 99%
“…A Ca2+-sensitive ATPase has also been shown to be associated with the mitotic apparatus (25). The activity of this enzyme peaks during mitosis in many cell types (26,27). Moreover, the Ca2+-ATPase activity bas been identified with the smooth endoplasmic reticulum of mitotic cells (28 …”
Section: Discussionmentioning
confidence: 99%
“…There is less detailed information concerning the Ca"buffering ability of ER at the specific time and in the specific locality of mitotic events . MAs from various cell types have been shown to contain a membrane-bound Ca"-ATPase, the activity of which cycles in accord with the cell cycle (25,30). This raises the tantalizing possibility that membranous components of the MA are involved in Ca" sequestration, and there is a recent report of such activity by vesicles of isolated MAs (41).…”
Section: Ca ++ Buffering By Ermentioning
confidence: 99%
“…Because Ca" affects the structure and function of the MA as well as the triggering of mitosis, the ability to control intracellular Ca" levels in the nucleus and in the vicinity of the subsequently formed spindle must be important to the cell . A suggestion that the MA indeed contains Ca"-regulating elements comes from the description of a membrane-bound, Ca --activated ATPase in the MA of various cells (25,30). Ca' uptake has also been shown to be associated with the MA in vivo (20,21) and in vitro (41,42).…”
mentioning
confidence: 99%
“…The mitotic Cat+-ATPase is now postulated to be membrane bound and active in sequestering calcium within the microenvironment of the mitotic apparatus (40)(41)(42). Membrane vesicles, lamellae, and cisternae are prominent components of the mitotic apparatus in the living cell (15)(16)(17)(18) .…”
Section: Enzymatic Activitymentioning
confidence: 99%