Synthesis and Aggregation Behavior of Pluronic F127/Poly(lactic acid) Block Copolymers in Aqueous Solutions

Xiong, Xiang‐Yuan; Tam, Kam Chiu; Gan, L. H.

doi:10.1021/ma035292d

Cited by 110 publications

(80 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With the anticipation of further size reduction, the P123 concentration was increased to 3% (R 4 ) which is greater than its critical micellar concentration (CMC) [41,42]. Here we could find a host of 30 nm particles along with the presence of light shaded spherical area typical of the structure of block copolymer micelles after drying on a grid [43], Figure 1E. A higher magnification image revealed the presence of very small particles (~ 3-4 nm) localised onto the surface of one such spherical tri block copolymer-micelle, Figure 1F.…”

Section: Resultsmentioning

confidence: 86%

Block copolymer mediated stabilization of sub-5 nm superparamagnetic nickel nanoparticles in an aqueous medium

et al. 2009

View full text Add to dashboard Cite

The paper presents a facile method for decreasing the size of water dispersible Ni nanoparticles from 30 nm to 3 nm by the incorporation of a passivating surfactant combination of pluronic triblock copolymer and oleic acid into a wet chemical reduction synthesis. A detailed study revealed that the size of the Ni nanoparticles is critically governed not only by the concentration of the tri block copolymers but also dependent on the hydrophobic nature of the micelle-core formed. The synthesized Ni nanoparticles were thoroughly characterized by TEM, XRD, XPS and temperature and field dependent magnetic measurements along with a comprehensive FTIR analysis to predict a possible mechanism of formation. Mirkin and co-workers demonstrated the efficient and selective separation of His-tagged proteins using Ni-based nanorods with a diameter of about 300 nm [15]. Hyeon and co-workers have successfully proved that superparamagnetic Ni with NiO shells have a high affinity for poly histidine and can be utilized for separating and purifying His-tagged proteins from a multicomponent solution [16]. Introduction.Ni nanoparticles can be synthesised in both organic and aqueous media. The high temperature decomposition of nickel carbonyl compounds [17] or Ni(acac) 2 compounds [18] in the presence of oleylamine, tri octyl phosphine oxide (TOPO) and tri octyl phosphine (TOP) [19] are common organic routes. While these methods are capable of producing monodispersed Ni with sub 5 nm size range, partial oxidation on the surface of the particles occurs readily even with the use of more than one capping agent [19]. Furthermore, the complexity involved in the above synthetic procedures is quite evident, requiring many steps, higher temperature, inert atmosphere and the use of non-regular, toxic chemicals. Microemulsion based methods using mixtures of polar and non polar solvents have also

show abstract

Section: Resultsmentioning

confidence: 86%

Block copolymer mediated stabilization of sub-5 nm superparamagnetic nickel nanoparticles in an aqueous medium

et al. 2009

View full text Add to dashboard Cite

show abstract

“…They proposed the micelles to possess high thermodynamic stability and suitable as long circulating carriers in the context of antineoplastic and antibiotic drug delivery [276]. The hydrolytic degradation of poly(lactic acid)-Pluronic F127-poly(lactic acid) nanoparticles has been reported by Xiong et al [277,278]. They noted that the hydrolytic degradation of the amphiphilic block copolymers affected the sizes and morphologies of these nanoparticles.…”

Section: Factors Important For Targeting Related To Polymeric Micellesmentioning

confidence: 98%

Polymeric micelles: authoritative aspects for drug delivery

Kulthe

Choudhari

Inamdar

et al. 2012

Designed Monomers and Polymers

192

View full text Add to dashboard Cite

“…The PEO-PPO-PEO block copolymer vesicles with high stability should provide various opportunities for material, biological and medical applications such as drug delivery system [25]. Thus, several approaches have been attempted to improve the stability of PEO-PPO-PEO block copolymer vesicles, polymer vesicles (polymersomes) and nonionic surfactant vesicles (noisomes): utilization of hydrophobic block copolymers such as poly(ethylene oxide)-poly(ethyl ethylene) [26], poly(ethylene oxide)-cholesterol [27], poly(ethylene oxide)-poly(propylene oxide)-poly(lactic acid) [28] or mixing of polymers, surfactants and hydrophobic components, for example, Pluronic P123/sodium dodcyl sulfate/NaF mixture [29], Pluronic L121/Pluronic P85/pentaerythritol tetraacrylate mixture [30], a poly(ethylene glycol)/Tween 80/Span 80 mixture [31][32][33][34][35], nonionic surfactant/cholesterol mixture [36,37], poly(ethylene glycol)-b-poly(sodium methacrylate)/cationic surfactant mixture [38], poly(ethylene glycol)-b-poly(acrylic acid)/azobenzene-containing surfactant mixture [39] and poly(ethylene oxide)-b-poly(1,2-butylene oxide)/ionic surfactant mixture [40].…”

Section: Introductionmentioning

confidence: 99%

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Sakai

Kurosawa

Okada

et al. 2011

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Fabrication of vesicles with the diameter of 4-30 m was achieved by mixing of a hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.

show abstract

Synthesis and Aggregation Behavior of Pluronic F127/Poly(lactic acid) Block Copolymers in Aqueous Solutions

Cited by 110 publications

References 36 publications

Block copolymer mediated stabilization of sub-5 nm superparamagnetic nickel nanoparticles in an aqueous medium

Block copolymer mediated stabilization of sub-5 nm superparamagnetic nickel nanoparticles in an aqueous medium

Polymeric micelles: authoritative aspects for drug delivery

Vesicle formation in mixture of a PEO-PPO-PEO block copolymer (Pluronic P123) and a nonionic surfactant (Span 65) in water

Contact Info

Product

Resources

About