Synthesis and amide imidic prototropic tautomerization in thiophene-2-carbohydrazide: XRD, DFT/HSA-computation, DNA-docking, TG and isoconversional kineticsviaFWO and KAS models

Abstract

Thiophene-2-carbohydrazide as a novel small-molecule amide tautomer has been synthesized with an acceptable yield under microwave radiation (MW) conditions.

Probing the Intermediates of Catalyzed Dehydration Reactions of Primary Amide to Nitrile in Plasmonic Junctions

“…As shown in the first two steps, the reaction is initiated by the amide–iminol tautomerism, induced by the relocation of a proton from the nitrogen atom to the oxygen atom in the primary amide group . The proton transfer is often assisted by the nearby water molecule or gold surface.…”

Co (II), Ni (II), and Cu (II) complexes of 4,6‐bis(2‐hydroxynaphthalen‐1‐yl)methyl‐ene)hydrazono)ethyl)benzene‐1,3‐diol: Synthesis, spectroscopic, biological, and theoretical studies

“…These advantages include (i) their strong DNA binding capability and (ii) the highly selective permeability of Cu (II) ions through the cell membrane of cancer cells. [ 61,62 ] Similarly, Co (II) and Ni (II) complexes exhibited beneficial properties including (i) low toxicity, (ii) easy penetration of the cell membrane of microorganisms and (iii) treatment of various diseases. [ 63,64 ]…”

“…These advantages include (i) their strong DNA binding capability and (ii) the highly selective permeability of Cu (II) ions through the cell membrane of cancer cells. [61,62] Similarly, Co (II) and Ni (II) complexes exhibited beneficial properties including (i) low toxicity, (ii) easy penetration of the cell membrane of microorganisms and (iii) treatment of various diseases. [63,64] Based on the previously mentioned facts and as an expansion of our interest in hydrazones derived from DAR, [28] the current study aims to synthesize a new bis (tridentate) hydrazone ligand, 4,6-bis(2-hydroxynaphthalen-1yl)methylene)hydrazono) ethyl)-benzene-1,3-diol, DHNAPH (Scheme 1), and investigate its coordinating ability toward cobalt (II), nickel (II), and copper (II) ions.…”

Synthesis and physicochemical, DFT, thermal and DNA-binding analysis of a new pentadentate N3S2 Schiff base ligand and its [CuN3S2]2+ complexes

“…[8][9][10] Recently, several reports have shown that these ligands and their complexes can be used toward the design of new drug candidates exhibiting anti-cancer, enzyme inhibition, anti-malarial, antifungal, antibacterial, and anti-inammatory activity. [8][9][10][11][12][13][14][15][16] Copper is essential in the human body and plays a critical role in biological processes involving electron transfer reactions. In fact, Cu(II) complexes bearing {S, O, N} donor chelating ligands are excellent anti-cancer agents because of their strong DNA binding ability.…”

“…[4][5][6][7][8][9][10] Due to the highly selective permeability of copper(II) ions through the cell membrane of cancer cells, copper is considered to be one of the most effective anti-tumor agents with low cost and few side effects. [7][8][9][10][11][12][13][14][15][16] Thus, various complexes bearing several types of ligand have been prepared and evaluated against cancer cells. [12][13][14][15][16][17][18][19][20][21][22][23][24] Pentadentate Schiff base ligands have received less attention as compared to mono-, di-, tri-, and tetradentate ligands due to the difficulty in their synthesis and unexpected multimode coordination behavior.…”