Synthesis and analgesic activity of some triazoles and triazolothiadiazines

(E)-N-benzylidene-3-(benzylthio)-5-p-tolyl-4H-1,2,4-triazol-4-amine, C23H20N4S

“…In recent decades, compounds containing the 1,2,4-triazole group have attracted much interest because of their exhibiting various biological activities [3][4][5][6][7]. Recently, (E)-3-substituted-4-arylideneamino-5-arylthiol (or alkylthiol)-4H-1,2,4-triazoles have been reported to possess antioxidant, herbicidal, antifungal antineoplastic, and etc [6].…”

Facile Synthesis and Antimicrobial Activities of 5H-[1,2,4]triazol[1,3,4]thiadiazine Derivatives

“…All the synthesized thiadiazines derivatives evaluated for antimicrobial activities in vitro using agar-plate diffusion technique 18 by measuring the zone of inhibition in mm. The antibacterial activity was evaluated against bacteria Escherichia coli ATCC25922 (E. coli), Pseudomonas aeruginosa ATCC 27853 (P. aeruginosa), Staphylococcus aureus ATCC 25923 (S. aureus) and Bacillus megaterium ATCC 14518 (B. megaterium) at 40 µg/mL concentration of samples with standard drugs amoxicillin and ciprofloxacin.…”

“…The 1,3,4-thiadiaznie derivatives in which 1,4-thiazines fused with 1,2,4-triazole nucleus are important scaffold in several natural and synthetic compounds of significant pharmacological properties and also have structural similarity with biologically most active phenothiazines in having fold along N-S axis 5 . These heterocycles have diverse applications as powerful antibacterial [6][7][8][9] , anti-mycobacterial 10,11 , antimitotic 12,13 , antifungal 14,15 , antidepressant 16,17 , analgesic 18 , anti-inflammatory, anticonvulsant 19 , antihypertensive 20 , antitumorial 21.22 , antiviral 23 , antiplatelet 24 and antithrombotic 25 .…”

Potentiometric Determination of Pharmaceutically Important Nimesulide in Non-Aqueous Medium

“…4,5-Substituted products containing 1,2,4-triazole in their molecules seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds and ligands useful in coordination chemistry 14 . Derivatives of 4,5-substituted 1,2,4-triazole were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides 15 . In addition there are some studies on electronic structures and thiol-thione tautomeric equilibrium of heterocyclic thione derivatives [16][17][18][19] .…”