Synthesis and anti-angiogenesis activity of coumarin derivatives

C-H···π and C-H···O Interactions in Coumarin 6 : 3-(2-benzothiazolyl)-7-(diethylamino)-coumarin

“…Coumarins are of interest because they constitute an important class of compounds, occupying a special place in nature and they form sub-units of many natural products. Coumarin and its derivatives are also widely used as additives in food, perfumes, cosmetics, pharmaceuticals, and agrochemicals 1,2) . Courmarins owe their commercial importance to their efficient light emission properties, their reasonable stability and their relative ease of synthesis.…”

Current developments of coumarin-based anti-cancer agents in medicinal chemistry

“…It was found that the introduction of benzothiazolyl group at C-3 position of coumarin ring had positive effect on inhibitory profile and presence of a cyano group at the fourth position offered the selectivity towards HUVEC (Fig. 9) [69].…”

Inhibition of amyloid-β aggregation by coumarin analogs can be manipulated by functionalization of the aromatic center

“…Most of the syntheses followed reported protocols. [20][21][22][23] The formation of the triazole rings used the standard Cu(I)-catalyzed alkyne-azide cycloaddition reaction initiated from coumarin azides. 20,24,25 Cyanocoumarins were synthesized by direct cyanation with sodium cyanide at room temperature (Scheme 2), which could readily react with sodium azide to afford tetrazole analogs 3 and 13, using Sharpless tetrazole synthesis.…”