Abstract:Sorafenib is recommended as the primary therapeutic drug for patients with hepatocellular carcinoma. To discover a new compound that avoids low response rates and toxic side effects that occur in sorafenib therapy, we designed and synthesized new hybrid compounds of sorafenib and 2,4,5-trimethylpyridin-3-ols. Compound
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was selected as the best of 24 hybrids that inhibit each of the four Raf kinases. The anti-proliferative activity of
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in HepG2, Hep3B, and Huh7 ce… Show more
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