Synthesis and anti-hepatocellular carcinoma evaluation of salicylic acid-modified indole trimethoxy flavonoid derivatives

Yang, Ziqiang; Lü, Na; Yang, Xiao‐Jun; Xie, Zhipeng; Lei, Xiaoyong; Liu, Xingyun; Li, Yong; Hu, Sheng; Tang, Guotao; Wang, Zhe

doi:10.1039/d3md00128h

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Molecular docking technology can simulate the results of drug-target interactions [63], making it easier to screen for anticancer drugs. At present, flavonoids [64][65][66], alkaloids, phenolic alcohols [67], and other TCM extracts in natural products have been found to exhibit strong anti-cancer activity in HCC treatment.…”

Section: Research On Natural Products Against Hccmentioning

confidence: 99%

Research progress on natural products against hepatocellular carcinoma

ZHANG,

LI,

MAO

2024

BIOCELL

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Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research.Particularly, we provide an outline of the various types of natural products, their corresponding nomenclature, target molecules, and mechanisms of action that exhibit anti-HCC activities. Natural products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer, potentially offering patients improved survival rates and an enhanced quality of life.

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Section: Research On Natural Products Against Hccmentioning

confidence: 99%

Research progress on natural products against hepatocellular carcinoma

ZHANG,

LI,

MAO

2024

BIOCELL

View full text Add to dashboard Cite

show abstract

“…Further experiments showed that compound 8f induced apoptosis in a concentration-dependent manner and down-regulated the expression of PKM2, PFKM, HK2 and tumor angiogenesis-related vascular endothelial growth factor. 102…”

Section: Phenylpropanoid-indole Derivativesmentioning

confidence: 99%

“…Further experiments showed that compound 8f induced apoptosis in a concentrationdependent manner and down-regulated the expression of PKM2, PFKM, HK2 and tumor angiogenesis-related vascular endothelial growth factor. 102 Cinnamic acid is an organic acid isolated from Cinnamomum verum bark that possesses anti-tumor, 103 antioxidant, 104 tyrosinase inhibitory 105 anti-bacterial 106 and other bioactivities. Pharmacochemistry researchers have modified the structure of cinnamic acid, hoping to obtain new drugs with research value such as anti-tumor, anti-oxidation and anti-bacterial activities.…”

Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%