Synthesis and Anti-Herpes Activity of a Series of Indolizines

Foster, C. M.; Ritchie, Mike; Selwood, David L.; Snowden, Wendy

doi:10.1177/095632029500600502

Cited by 14 publications

(9 citation statements)

References 19 publications

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“…Indolizine derivatives exhibit antioxidative (Teklu et al, 2005), antiherpes (Foster et al, 1995), anti-inflammatory (Malonne et al, 1998) and antiviral (Medda et al, 2003) activities. In addition, indolizines are used as antimycobacterial agents against mycobacterial tuberculosis (Gundersen et al, 2003).…”

Section: S1 Commentmentioning

confidence: 99%

Methyl 9-(4-bromophenyl)-8a,9,9a,10,11,12,13,14a-octahydro-8H-benzo[f]chromeno[3,4-b]indolizine-8a-carboxylate

et al. 2009

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Section: S1 Commentmentioning

confidence: 99%

Methyl 9-(4-bromophenyl)-8a,9,9a,10,11,12,13,14a-octahydro-8H-benzo[f]chromeno[3,4-b]indolizine-8a-carboxylate

et al. 2009

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“…Synthesis of biologically active indolizine derivatives continues to attract the attention of organic chemists as potent pharmaceutical drugs due to their wide spectra of activities e.g. antioxidative, antiinflamatory, antibacterial, antifungal, antitumor, antiherpes and antinociceptive (Vemula et al, 2011;Nasir et al, 1998;Teklu et al, 2005;Grundersen et al, 2003;Kubo et al, 1996;Pearson & Guo, 2001;Foster et al, 1995;Vaught et al, 1990;Couture et al, 2000). Toyota et al (2003) have recently reported that some indole alkaloids show antiviral properties due to the presence of the indolizine ring system in their structure.…”

Section: Introductionmentioning

confidence: 98%

Newly synthesized indolizine derivatives – antimicrobial and antimutagenic properties

Olejníková¹,

Bírošová²,

Švorc

et al. 2015

Chemical Papers

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A series of indolizine derivatives have been synthesized and subjected to antibacterial screening studies. Antibacterial activity of 21 derivatives was investigated against Staphylococcus aureus, Mycobacterium smegmatis, Salmonella typhimurium and Escherichia coli; also, the sensitivity of model yeast Candida parapsilosis and some model filamentous fungi Aspergillus fumigatus, Alternaria alternata, Botrytis cinerea and Microsporum gypseum was tested. Newly synthesized indolizine derivatives have shown selective toxicity to Gram-positive bacteria S. aureus and were also considered to be able to inhibit the acidoresistant rod M. smegmatis. Derivative XXI has shown the highest inhibition effect with the bacteriostatic effect on the cells at the concentration of 25 µg mL −1 . The best antifungal activity has been detected in the presence of derivative XIII. Derivative XIII did also affect the morphology of hyphal tips of B. cinerea, which led to enhanced ramification of hyphae. Finally, the antimutagenic activity of derivatives was investigated. Significant antimutagenic activity was registered in case of derivative VIII. The number of induced revertants by mutagen [2-(5-nitrofuryl)acrylic acid] was decreased almost to the level of spontaneous revertants in the lowest applied concentration (50 µg per plate).

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“…Indolizines have also been tested as antimycobacterial agents against mycobacterial tuberculosis (Gundersen, et al, 2003). Many studies have proved that indolizine derivatives possess biological activities such as antioxidative (Teklu et al, 2005) and antiherpes (Foster et al, 1995). Other well known pharmacological applications associated with this ring compounds are well documented in literature (Couture et al, 2000;Jorgensen et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Crystal, molecular and electronic structure of (3aS,4S,9aS,9bR)-4-ethyl-2,2-dimethylhexahydro-[1,3]dioxolo[4,5-g] indolizin-7(3aH)-one

Vrábel

Sivý

Šafář

et al. 2015

Acta Chimica Slovaca

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Molecules of the title compound, C13H21NO3, crystallize as single enantiomers with four stereogenic centres, their absolute configuration were confirmed by anomalous dispersion effects determined by diffraction measurements on the crystals. Conformations of the pyrrolidine and 1,3-oxolane rings are close to that of an envelope, with the flap atoms displaced by −0.205 (1) and −0.449 (1) Å, respectively, from the plane of the other remaining four atoms. The central six-membered ring of the indolizine moiety adopts a nearly perfect boat conformation, with two atoms displaced by 0.575 (1) and 0.603 (1) Å from the plane of the other remaining four atoms. Crystal structure of the title compound is stabilized by C−H···O hydrogen interactions.

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Synthesis and Anti-Herpes Activity of a Series of Indolizines

Cited by 14 publications

References 19 publications

Methyl 9-(4-bromophenyl)-8a,9,9a,10,11,12,13,14a-octahydro-8H-benzo[f]chromeno[3,4-b]indolizine-8a-carboxylate

Methyl 9-(4-bromophenyl)-8a,9,9a,10,11,12,13,14a-octahydro-8H-benzo[f]chromeno[3,4-b]indolizine-8a-carboxylate

Newly synthesized indolizine derivatives – antimicrobial and antimutagenic properties

Crystal, molecular and electronic structure of (3aS,4S,9aS,9bR)-4-ethyl-2,2-dimethylhexahydro-[1,3]dioxolo[4,5-g] indolizin-7(3aH)-one

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