Synthesis and anti‐HIV Activity of New Chiral 1,2,4‐Triazoles and 1,3,4‐Thiadiazoles.

Abstract

5-substituted 4-(4-chlorophenyl)-4H-1,2,4-triazol-3-thiones

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

“…In 13 C-NMR of compounds 7 – 9 the C-3 and C-5 heterocyclic carbon from triazole nucleus resonated at 169.52–169.54 and 149.01–149.03 ppm, respectively. The signal of the C-3 quaternary carbon atom at ~169 ppm is characteristic of C=S group [12,13,41,42,43] which indicates the presence of the thione tautomeric form in solution. The most significant proof of the alkylation of triazoles 7 – 9 with 2-bromoacetophenone or 2-bromo-4'-fluoroacetophenone was the presence in 13 C-NMR spectra of compounds 10 – 12 and 13 – 15 of two new signals at 191.42–192.73 and 40.33–40.46 ppm corresponding to C=O and S-CH 2 carbon atoms from a phenacyl/4-fluorophenacyl group.…”

In vitro antibacterial, antifungal and cytotoxic activities of some triazole Schiff bases and their oxovanadium(IV) complexes

“…1,2,4-Triazoles have been known for a potential use in a wide variety of therapeutically interesting drugs including CNS stimulant, anti-anxiety 2 and also antimycotic compounds such as fluconazole, intraconazole and voriconazole 3 . In view of the significant therapeutic uses, the chemistry of 1,2,4-triazoles represents an important class of compounds owing to their synthetic and effective biological properties like antibacterial 4 , antifungal 5 , anticonvulsant 6 , antiproliferative 7 , antitumor 8 , antitubercular 9 , anticancer 10 , anti HIV 11 and antiviral 12 . Vanadium chemistry has established its strong role as antimicrobial 13 , anti-tumor 14 , anti-leukemic 15 , spermicidal 16 , anti-amoebic 17 , antioxidant 18 and osteogenic 19 activity in bioinorganic chemistry.…”

Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid

“…As a result of our focus on the synthesis and biological evaluation of five-membered heterocycles [11][12][13] , in the present study, 2,5-disubstituted-1,3,4-oxadiazoles and 4,5-disubstituted-1,2,4-triazole-3-thiones were synthesized starting from mandelic acid (Scheme 1) and their urease inhibition evaluated.…”