Synthesis and anti-HIV activity of alkylated quinoline 2,4-diols

Enantiodivergent Transannular Rearrangement of 3‐Isopropyl‐1,4‐benzodiazepine‐2,5‐dione by Memory of Chirality

“…[7] Nevertheless, quinoline-2,4-diones with a quaternary carbon center at C-3 possess anti-HIV [8] and 5-HT 6 serotonin receptor antagonistic activities. [9] This skeleton is also found in buchapine, a biologically active natural product with therapeutic potential.…”

Synthesis and <i>In Vitro</i> Antibacterial and Antifungal Evaluation of Quinoline Analogue Azetidin and Thiazolidin Derivatives

“…So we have tried to follow green methods for the synthesis, as far as possible. During our literature for the synthesis of quinoline derivatives, Nafees Ahmed et al studied structural activity relationship of quinoline-2,4-diols for anti-HIV activity and they also conclude that the activity is due to unsubstituted ring B and two free -OH groups [6]. Therefore, we found quinoline-2,4-diol having hydroxyl group at 2 nd and 4 th positions will became quite interesting for the study.…”

“…They also exhibit anti-tubercular and immune depressant activities [2]. Few promising compounds with the quinoline ring system like, pamaquine (1), chloroquine (2), tafenoquine (3), bulaquine (4), quinine (5) and mefloquine (6) as an antimalarial agent and amodiaquine (7) as an antimalarial as well as anti-inflammatory agent (Figure 1) [3][4][5].…”

Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs

“…It demonstrates a broad range of biological activity such as antimalarial [8], antituberculosis [9], anti-HIV [10], antifungal, antibacterial, antiprotozoic and antibiotic activities [11]. N-Functionalized morpholine motifs have been recognized to possess diversified biological activities such as antiemetic [12,13], antidiabetic [14], inflammatory migraine and asthma [15,16], platelet aggregation inhibitors [17].…”