2022
DOI: 10.14233/ajomc.2022.ajomc-p365
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Synthesis and Anti-inflammatory Activity of Newer Indolyl Pyrazolines and Indolyl Isoxazolines

Abstract: Various 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)-2-pyrazolines (9-15) and 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)isoxazolines (16-22) have been synthesized by the cyclization of compounds 1-(2′-carboxyl-5′-methoxyindolyl-3-arylidenyl chalcones (2-8) by treating them with hydrazine hydrate/glacial acetic acid and hydroxylamine hydrochloride/2% NaOH, respectively and TLC checked for their purity. Structure of all these newly synthesized compounds was characterized by elemental (C, H, N) an… Show more

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