Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives

Fayed, Ahmed A.; Alahmadi, Yaser M.; Yousif, Mahmoud N. M.; Yousif, N. M.; Amer, Atef M.; El‐Farargy, Ahmed F.; Ouf, Nabil H.; Gad, F. A.

doi:10.1134/s1070363219090251

Cited by 17 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the presence of N ‐heterocyclic carbene, the reaction of ketenes with α‐cyanochalcones gave the corresponding chiral multisubstituted dihydropyranones (Figure 17). [76] A pyrimidinopyrazolo‐pyridazine (Figure 17) was obtained [77] through the reaction of α‐CN‐chalcone with 5‐amino phenanthro‐[9,10‐e]‐3 H ‐pyrazolo[3,4‐c]pyridazine. The antimicrobial activity of the prepared pyridazine was evaluated.…”

Section: Different α‐Substituted Chalconesmentioning

confidence: 99%

α‐Substituted Chalcones: A Key Review

Al-Rifai

Mubarak

2021

ChemistrySelect

View full text Add to dashboard Cite

Chalcones are attractive chemical motifs with various biological activities. Aryl substituted chalcones have been extensively studied and reviewed through the years. However, α‐substituted chalcones have rarely been investigated. Hence, this review highlights the α‐substituted chalcones: their synthetic routes, reported biological activities, and transformations to other organic compounds. To the best of our knowledge, this would be the first comprehensive review about α‐substituted chalcones. α‐Substitution of chalcones represents a promising approach to tune their reactivity since it has a direct influence on their activity as Michael acceptors. Additionally, α‐substitution has its effect on the structure and conformation of chalcones. Altering the reactivity of chalcones by α‐substitution has a great impact on their biological activity.

show abstract

Section: Different α‐Substituted Chalconesmentioning

confidence: 99%

α‐Substituted Chalcones: A Key Review

Al-Rifai

Mubarak

2021

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…All the aforementioned biological activities and our previous work (El-Gazzar et al, 2008;Fayed and Yousif, 2019;Fayed et al, 2019aFayed et al, , 2019bNemr et al, 2019;Soliman et al, 2014;20182019c;2020;2021) directed us to prepare novel chromene derivatives and measure the cytotoxic activity of the prepared compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and cytotoxic evaluation of novel chromenes and chromene(2,3-d)pyrimidines

Yousif¹,

El‐Gazzar²,

Fayed³

et al. 2020

J Appl Pharm Sci

View full text Add to dashboard Cite

“…[ 28,29 ] Moreover, pyrazolopyrimidines exhibit a range of activities, including Central Nervous System (CNS) depressant, antitumor, antileukemic, antimicrobial against Gram‐positive bacteria, antileishmanial, and antihypertensive activities. [ 30–33 ]…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pyrazolopyrimidines in mild conditions by gold nanoparticles supported on magnetic ionic gelation in aqueous solution

Xing

Zheng

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

In this study, novel magnetic nanoparticle (FeNi3) based gold NPs with high surface area and easy accessibility of active sites were successfully developed by a facile approach. FeNi3 was functionalized with ionic gelation (IG) groups acting as robust anchors so that the gold NPs were well dispersed on the FeNi3 without aggregation. Spirulina coating was carried out via a wet impregnation technique based on IG using tripolyphosphate as a cross‐linking agent. Because of the amplification effect of IG, high loading capacities were achieved for the nanocatalysts. Furthermore, FeNi3/IG/Au showed superparamagnetic properties, contributing to the easy recovery of the nanocatalysts by magnetic separation. FeNi3/IG/Au was developed for the synthesis of pyrazolopyrimidines in mild conditions. The FeNi3/IG/Au magnetic NPs were thoroughly characterized using transmission electron microscopy, field emission scanning electron microscopy, vibrating sample magnetometry, Fourier‐transform infrared spectroscopy, and thermogravimetric analysis. The FeNi3/IG/Au nanocatalyst showed high robustness and stability in reaction for up to five cycles without significant loss of activity, probably due to the high loading of IG in the catalyst.

show abstract

Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives

Cited by 17 publications

References 14 publications

α‐Substituted Chalcones: A Key Review

α‐Substituted Chalcones: A Key Review

Synthesis and cytotoxic evaluation of novel chromenes and chromene(2,3-d)pyrimidines

Synthesis of pyrazolopyrimidines in mild conditions by gold nanoparticles supported on magnetic ionic gelation in aqueous solution

Contact Info

Product

Resources

About