Synthesis and Anti-inflammatory Effects of Xanthone Derivatives

Lin, Chun‐Nan; Chung, Mei‐Ing; Liou, Shiou-Jyh; Lee, Tai‐Hua; Wang, Jip‐Pyang

doi:10.1111/j.2042-7158.1996.tb05969.x

Cited by 90 publications

(35 citation statements)

References 14 publications

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“…Xanthone molecules having a variety of substituents on the different carbons of the nucleus constitute a group of compounds with a broad spectrum of biological activities [1,2]. Among others, anti-inflammatory [3], hepatoprotective [4], immunomodulatory [5][6][7], modulatory activity of PKC isoforms [8,9] and antitumor activities of the growth of human cancer cell lines [7].…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone

Teixeira

Alonso

Pinto

et al. 2005

European Journal of Pharmaceutics and Biopharmaceutics

161

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The aim of the present work was to develop and characterize two different nanosystems, nanospheres and nanocapsules, containing either xanthone (XAN) or 3-methoxyxanthone (3-MeOXAN), with the final goal of improving the delivery of these poorly water-soluble compounds. The xanthones-loaded nanospheres (nanomatrix systems) and nanocapsules (nanoreservoir systems), made of poly(DL-lactideco-glycolide) (PLGA), were prepared by the solvent displacement technique. The following characteristics of nanoparticle formulations were determined: particle size and morphology, zeta potential, incorporation efficiency, thermal behaviour, in vitro release profiles and physical stability at 4 8C. The nanospheres had a mean diameter !170 nm, a narrow size distribution (polydispersity index !0.1), and a negative surface charge (zeta potential !K36 mV). Their incorporation efficiencies were 33% for XAN and 42% for 3-MeOXAN. The presence of the xanthones did not affect the nanospheres size and zeta potential. DSC studies indicated that XAN and 3-MeOXAN were dispersed at a molecular level within the polymeric nanomatrix. Nanocapsules were also nanometric (mean size !300 nm) and exhibited a negative charge (zeta potential !K36 mV). Their incorporation efficiency values (O77%) were higher than those corresponding to nanospheres for both xanthones. The release of 3-MeOXAN from nanocapsules was similar to that observed for the correspondent nanoemulsion, indicating that drug release is mainly governed by its partition between the oil core and the external aqueous medium. In contrast, the release of XAN from nanocapsules was significantly slower than from the nanoemulsion, a behaviour that suggests an interaction of the drug with the polymer. Nanocapsule formulations exhibited good physical stability at 4 8C during a 4-month period for XAN and during a 3-month period for 3-MeOXAN. q

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Section: Introductionmentioning

confidence: 99%

Development and characterization of PLGA nanospheres and nanocapsules containing xanthone and 3-methoxyxanthone

Teixeira

Alonso

Pinto

et al. 2005

European Journal of Pharmaceutics and Biopharmaceutics

161

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“…The xanthones area class of natural products with several pharmacological properties, such as anti-inflammatory, [34] antimicrobial, [35] antioxidants, [36] antifungal [37] and anticancer activities [38] . In addition, crude extracts obtained from the fungi described here were evaluated against four Salmonella species, and all of the fungal extracts showed antimicrobial activity [39] .…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of endophytic fungi in the medicinal plant Mikania laevigata (Asteraceae)

Ribeiro¹,

Kamida²,

Almeida³

et al. 2014

Phcog J.

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The Mikania laevigata (Asteraceae) is a Brazilian medicinal plant used to treat respiratory tract diseases. It is produced on a large scale for phytotherapic formulation. No studies on the endophytes of Mikania laevigata have been described in the literature. The endophytic fungi isolated from the leaves of M. laevigata cultivated in a floral garden located in the south region of the Bahia state, Brazil, were investigated. After surface disinfection, the performing the isolation procedure, a total of forty endophytic fungi were obtained and grouped into different morphospecies. The fungi were characterized by molecular sequencing the ITS rDNA regions, and they were identified by comparing the results published Gen Bank sequences.The phylogenetic analyses revealed four major clades of fungi from the sequenced ITS-rDNA regions: Nodulisporium sp. (3 isolates), Hypoxylon sp. (3 isolates), Daldinia sp. (1 isolate) and Xylaria luteostromata (aunique isolate).The Xylariaceae Genus was the dominant group of fungi associated with Mikania laevigata.

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“…The study leadered by Healy et al (2004) resulted on the isolation of xanthones, compounds isolated from endophytic fungi identified as Xylaria sp. The fungus isolated from Glochidion ferdinandi plant, and the metabolites extracted showed important pharmacological activities (Peres & Nagem, 1996;Peres et al, 2000) as for example, anti-inflammatory (Lin et al, 1996), antimicrobial (Malet-Cascon et al, 2003), antioxidants (Minami et al, 1994), antifungical (Rocha et al, 1994) e anticancer properties (Ho et al, 2002). Krohn et al (2004), developed an similar research, describing the syntesis of xyloketal D, a natural product that belongs to a group of secondary metabolites isolated from Xylaria sp.…”

Section: Xylariaceae Metabolites Biological Activitymentioning

confidence: 99%