Synthesis and Anti-Inflammatory Evaluation of 3-Methylthio-1,2,4-Triazines, 3-Alkoxy-1,2,4-Triazines, and 3-Aryloxy-1,2,4-Triazines

Heilman, William P.; Heilman, Richard D.; Scozzie, James A.; Wayner, Robert J.; Gullo, James M.; Ariyan, Z. S.

doi:10.1002/jps.2600690310

Cited by 21 publications

(9 citation statements)

References 18 publications

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“…Schiff bases derived from 1,2,4 triazine are known to be biologically active. They act as antiviral (Dandson and Boykin, 1978), antibacterial, antimalarial and antiinflammatory agents (Heilman et al, 1980). Synthesis of new Schiff bases and their metal complexes still the aim of many recent investigations (Lacroxi et al, 2004;Golcu et al, 2005;Dhar et al, 2005;Peppel and Kockerling, 2009).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine

et al. 2011

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Coordination complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff base derived from syringaldehyde and 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine have been synthesized. These complexes have been characterized by elemental analysis, magnetic moment, spectroscopic (IR, Electronic, 1 H NMR, ESR) and thermogravimetric analysis. Magnetic and spectral data suggest octahedral geometry for Co(II), Ni(II) and Zn(II) complexes and square planar for Cu(II) complexes. The presence of coordinated water in metal complexes was confirmed by thermal and IR data. The Schiff base and its metal complexes have been screened for antibacterial (Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, Staphylococcus aureus) and antifungal activities (Aspergillus niger, A. flavus). A comparison is made between activities of complexes with Schiff base and with the standard antibiotics.

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Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine

et al. 2011

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“…74 150–152 °C). 1 H NMR (300 MHz, CDCl 3 ) δ 9.29 (s, 1 H), 7.73–7.68 (m, 2 H), 6.97 (d, J = 8.3 Hz, 1 H), 3.97 (s, 3 H), 3.95 (s, 3 H), 2.70 (s, 3 H); 13 C NMR (75 MHz, CDCl 3 ) δ 173.2, 153.9, 153.1, 149.7, 141.6, 125.4, 121.4, 110.1, 109.7, 56.1, 56.0, 13.9.…”

Section: Methodsmentioning

confidence: 99%

“…74 153–154 °C). 1 H NMR (300 MHz, CDCl 3 ) δ 9.32 (s, 1 H), 7.98 (m, 2 H), 7.64 (m, 2 H), 2.69 (s, 3 H).…”

Section: Methodsmentioning

confidence: 99%

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Banerjee

Molland

et al. 2014

Bioorganic & Medicinal Chemistry

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Inorganic pyrophosphatases are potential targets for the development of novel antibacterial agents. A pyrophosphatase-coupled high-throughput screening assay intended to detect o-succinyl benzoic acid coenzyme A (OSB CoA) inhibitors led to the unexpected discovery of a new series of novel inorganic pyrophosphatase inhibitors. Lead optimization studies resulted in a series of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazine derivatives that were prepared by an efficient synthetic pathway. One of the tetracyclic triazine analogues 22h displayed promising antibiotic activity against a wide variety of drug-resistant Staphylococcus aureus strains, as well as activity vs. Mycobacterium tuberculosis and Bacillus anthracis, at a concentration that was not cytotoxic to mammalian cells.

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“…Hydration Schiff base compounds containing quinoline moiety are well known in natural materials, and show interesting biological and antiviral activities [1][2][3]. Many derivatives of hydration compounds form colored complexes with different metal ions and can be used as analytical reagents for their determinations [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…The coordination compounds of aroylhydrazones have been reported to act as enzyme inhibitors [10] and are useful due to their pharmacological applications [11][12][13]. The study of Schiff base hydrazones has been growing interest because of their antimicrobial, anti-tuberculosis, and anti-tumor activity [1][2][3][4][5][6][7][8][9][10][11][12]. The azomethine (C=N) linkage in Schiff bases imports in elucidating the mechanism of transmission and reexamination reactions in biological system [14].…”

Section: Introductionmentioning

confidence: 99%

Spectro-Potentiality and Thermodynamic Studies on Schiff Base Hydrazone Derivatives Complexes with Some Transition Elements

G¹

2015

J Thermodyn Catal

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Synthesis and Anti-Inflammatory Evaluation of 3-Methylthio-1,2,4-Triazines, 3-Alkoxy-1,2,4-Triazines, and 3-Aryloxy-1,2,4-Triazines

Cited by 21 publications

References 18 publications

Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine

Synthesis, spectroscopic, thermal and antimicrobial studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine

Synthesis of 3-(3-aryl-pyrrolidin-1-yl)-5-aryl-1,2,4-triazines that have antibacterial activity and also inhibit inorganic pyrophosphatase

Spectro-Potentiality and Thermodynamic Studies on Schiff Base Hydrazone Derivatives Complexes with Some Transition Elements

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