Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues

Maccioni, Elias; Cardia, Maria Cristina; Bonsignore, Leonardo; Plumitallo, Antonio; Pellerano, Maria Luisa; Logu, Alessandro De

doi:10.1016/s0014-827x(02)01288-0

Cited by 37 publications

(20 citation statements)

References 16 publications

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“…In this present work, thiazolylhydrazone derivatives (1a-e; 2a-e) were synthesized by in accordance with the method described in the literature [20,21]. Aryl ketones reacted with thiosemicarbazide to give the required thiosemicarbazones.…”

Section: Resultsmentioning

confidence: 99%

Studies on hydrazone derivatives as antifungal agents

Özdemir

Turan-Zitouni

Kaplancıklı

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-hydrazone (2a-e) derivatives were synthesised and evaluated for antifungal activity. Their antifungal activities against standard and clinical strands of Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, Candida zeylanoides, and Candida parapsilosis were investigated. A significant level of activity was observed.

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Section: Resultsmentioning

confidence: 99%

Studies on hydrazone derivatives as antifungal agents

Özdemir

Turan-Zitouni

Kaplancıklı

et al. 2008

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Mp = 343-344 °C. M/z = 292; 1 H nmr (DMSO-d 6 ): δ 7.85 (4H, t, Ar, J = 7.1, 2.9); 8.00 (4H, d, Ar, J = 7.1, 2.9); 13 …”

Section: Methodsmentioning

confidence: 99%

“…Pursuing our research in the field of antibacterial compounds [11][12][13], we attempted to repeat this procedure several times, in order to obtain derivatives of 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamide or -carbothioamide as potential antimycobacterial agents.…”

mentioning

confidence: 99%

Synthesis and biological activity evaluation of differently substituted 1,4‐dioxo‐3,4‐dihydrophthalazine‐2(1H)‐carboxamides and ‐carbothioamides

Cardia

Distinto

Maccioni

et al. 2003

Journal of Heterocyclic Chem

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Differently substituted phthalic anhydrides can react either with semicarbazide or thiosemicarbazide to give respectively 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides or 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carbothioamides under mild conditions and generally with good yields. These compounds have been tested in order to evaluate their anti-microbial activity. Furthermore a new synthetic pathway to phthalazino[2,3-b]phthalazine-5,7,12,14-tetraone has been devised

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“…Our research group has already studied similar scaffolds as antifungal and antibacterial agents and some of these compounds exhibited potent activity towards several species of Candida [21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida

Meleddu

Distinto

Corona

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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Cyclohexyliden-and 2-methylcyclohexyliden-hydrazo-4-arylthiazoles were synthesized and tested as antifungal agents. All compounds exhibited minimal inhibitory concentration (MIC) values comparable with those of fluconazole (FLC). Moreover, some compounds showed fungicidal activity at low concentration. Worth noting five out of nine compounds were active towards Candida albicans 25 FLC resistant isolated from clinical specimens. The cellular toxicity was evaluated and none of the compounds is toxic at the MIC. On the basis of our data we can conclude that these derivatives are promising agents for the treatment of resistant C. albicans.

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Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues

Cited by 37 publications

References 16 publications

Studies on hydrazone derivatives as antifungal agents

Studies on hydrazone derivatives as antifungal agents

Synthesis and biological activity evaluation of differently substituted 1,4‐dioxo‐3,4‐dihydrophthalazine‐2(1H)‐carboxamides and ‐carbothioamides

Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida

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