Synthesis and anti-microbial activity of pyrazolylbisindoles—Promising anti-fungal compounds

An eco-friendly procedure for the efficient synthesis of arylidinemalononitriles and 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) in aqueous media

“…More recently, we found that aldehydes reacted with malononitrile efficiently in the absence of catalyst and solvent under microwave irradiation and thermal heating conditions (13). 4,4?-(Arylmethylene)bis(1H-pyrazol)-5-ols are applied as fungicides (14), pesticides (15), dyestuffs (16), and as the chelating and extracting reagents for different metal ions (17). The conventional chemical approach to 4,4?-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazo l-5-ols) involves the successive Knoevenagel synthesis of the corresponding arylidinepyrazolones and its base-promoted Michael reaction and also one-pot tandem KnoevenagelÁMichael reaction of arylaldehydes with two equivalents of 3-methyl-1-phenyl-1 *Corresponding author.…”

Poly(4-vinylpyridine)-supported dual acidic ionic liquid: an environmentally friendly heterogeneous catalyst for the one-pot synthesis of 4,4'-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols)

“…16 Moreover, the corresponding 4,4'-(arylmethylene)bis(1H-pyrazol-5-ols) are used as insecticides, 17 pesticides, 18 dyestuffs, 19 and the chelating and extracting reagents for different metal ions. 20 One-pot tandem Knoevenagel-type condensation/Michael reaction between aromatic aldehydes with 2 equivalents of 3-methyl-l-phenyl-5-pyrazolone is one of the most pivotal preparation methods of 4,4'-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols).…”

A green protocol for the synthesis of bis(indolyl)methanes catalyzed by succinic acid under microwave irradiation

“…3 Bis(indolyl)methanes are known to promote beneficial estrogen metabolism and induce apoptosis in human cancer cell. 4a,b Other beneficial activities such as dietary supplements, 5 topoisomerase IIa inhibitors, 6 antibacterials, 7 antibiotics, 8 antifungal, 9 anti-inflammatory, 10 antimicrobialactivities, 11 agrochemicals, 12 and in material sciences as calorimetric sensors, particularly for various metals and fluorides. 13a, b Due to their broad range of biological applications, there is a great deal of interest in the synthesis of bis(indolyl)methane derivatives.…”