Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids

Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

“…In the present study, oral administration of celery extract inhibited the gastric damage caused by ethanol and strong alkali, the most commonly employed tests in the evaluation of anti-ulcer/cytoprotective activity (Oliveira et al, 2004). It is suggested that oxygen radicals may contribute to the induction of ethanol and other necrotizing agents-induced gastric mucosal lesions (Trier et al, 1987;Matsumoto et al, 1992) and anti-oxidants are protective against the damage caused by oxidants (Mizui et al, 1987;Farina et al, 1998). Ethanol has been shown to deplete the level of non-protein sulfhydryl content in stomach tissues and its restoration appears to be important in gastroprotection since they provide a substrate for free radicals to replenish GSH stores (Trier et al, 1987).…”

Synthesis and in Vitro Antioxidant Activity of Glycyrrhetinic Acid Derivatives Tested with the Cytochrome P450/NADPH System

“…6) Ia can be hydrolyzed into active aglycone, 18-beta-glycyrrhetinic acid (Ib). Both Ia and Ib have been shown to have several beneficial pharmacologic activities, such as antiinflammatory activity, 7) antiulcerative effect, 8) antiviral activity, 9) and antihepatitis effect. 10 Recently, Zakirov and Abdullaev 11) have demonstrated the effective antioxidant and hypolipidemic properties of ammonium salt of Ib.…”

Bioactive Component of Licorice as an Antileishmanial Agent

“…18β-Glycyrrhetinic acid (GRA), a pentacyclic triterpene derivative of the β-amyrin type, is obtained from the roots of Glycyrrhizza glabra L. It is known to exhibit a variety of pharmacological effects like antiulcerative, anti-hepatotoxic, anti-tumorigenic and immunoregulatory activities [14][15][16][17]. As evident, GRA has potent immunomodulatory effects, thus its potency as an antileishmanial agent and the underlying mechanism was thoroughly explored.…”