Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex

Sharma, K. K.; Chandra, Sudam; Basu, Debojyoti

doi:10.1016/s0020-1693(00)83260-0

Cited by 51 publications

(23 citation statements)

References 2 publications

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“…It has also been reported that curcumin-gold complex is an effective antiarthritic agent. 10 The present study suggests that metal complexation significantly increased the cytotoxic.and antitumour activities of compounds. As reported earlier, 9,19,20 the hydroxyl group in the phenyl ring enhances the antitumour activity.…”

Section: Effect Of Compounds On Solid Tumour Developmentsupporting

confidence: 50%

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

John¹,

Krishnankutty²

2006

Appl. Organometal. Chem.

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Four new curcuminoid analogues, 1,7-bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, 1a; 1,7-di(2-furyl)-1,6-heptadiene-3,5-dione, 1b; 1,7-di(2-naphthyl)-1,6-heptadiene-3,5-dione, 1c; 1,7-bis(2-chlorophenyl)-1,6-heptadiene-3,5-dione, 1d; and their copper(II) complexes of ML 2 stoichiometry were synthesized and characterized by UV, IR, 1 H NMR, ESR and mass spectral data. The compounds were investigated for their possible cytotoxic and antitumour activities. It was found that copper chelates are remarkably active compared with free curcuminoid analogues. All the compounds were found to be cytotoxic towards Ehrlich ascites carcinoma cells and cultured L929 (lung fibroblast cells). In the case of culture studies, concentrations needed for 50% cell death were around 5 µg/ml for copper complexes and 10 µg/ml for curcuminoid analogues. Copper complex of 1a with hydroxyl group in the phenyl ring was found to be most active towards L929cells (1 µg/ml produced 43.3 ± 1.3% cell death). Compound 1b, which possesses a furyl ring system, was found to show least activity towards increase in life span of tumour-bearing mice (increase in life span 39.31%). Copper chelates of all curcuminoid analogues showed a significant reduction (p < 0.001) of solid tumour volume in mice.

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Section: Effect Of Compounds On Solid Tumour Developmentsupporting

confidence: 50%

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

John¹,

Krishnankutty²

2006

Appl. Organometal. Chem.

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“…Several metal complexes of curcumin have been synthesized, characterized and evaluated for various biological activities. The [Au(curcumin) 2 Cl] was a five coordinate gold complex [13], which had anti-arthritic properties and assessed in an adjuvant-induced rat poly arthritis model. The [Cu(curcumin) 2 ] complexes [14] were most cytotoxic in cultured L929 cells and showed significant reduction in solid tumor volume in as cites tumor bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

et al. 2014

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Some ternary complexes of curcumin have been synthesized by the reaction of M(II) nitrate with curcumin as primary ligand and 1,10-phenanthroline (phen) as supporting ligand in water/ethanol solution under a nitrogen atmosphere. The composition of the complexes has been characterized by elemental analysis, molar conductivity, thermogravimetric analysis, IR, UV-vis spectroscopy. The results reveal that curcumin ligand coordinates with M(II) in bidentate mode after deprotonation. The supporting ligand (phen) uses its two N atoms in coordination with metal ions in bidentate mode. The general formula of the complexes is [M(Cur)(phen)]NO 3 (M = Ni(II), Co(II), Cu(II) and Z(II)). The results of antibacterial activity indicated that the complexes have good antibacterial ability for the testing bacterium than that of curcumin. Furthermore, the [M(Cur)(phen)]NO 3 complexes were evaluated for its in vitro anticancer activity against hepatocellular carcinoma.

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“…Several metal complexes of curcumin have been synthesized, characterized and evaluated for various biological activities. Au(curcumin) 2 Cl, a five coordinate of gold complex [5], has the properties of anti-arthritic and is assessed in an adjuvant-induced rat polyarthritis model. The Cu(curcumin) 2 complexes [6] are most cytotoxic in cultured L929 cells and show significant reduction in solid tumor volume in ascites tumor bearing mice.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

Song

Ding

et al. 2009

Journal of Inorganic Biochemistry

111

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Synthesis and antiarthritic study of a new orally active diferuloyl methane (curcumin) gold complex

Cited by 51 publications

References 2 publications

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

Antitumour activity of synthetic curcuminoid analogues (1,7-diaryl-1,6-heptadiene-3,5-diones) and their copper complexes

Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

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