Synthesis and antibacterial activity of 7-deacetoxy-7-hydroxygedunin

Abstract

A convenient synthetic route for bioactive 7-deacetoxy-7α-hydroxygedunin was realized by one-step conversion of 7-deacetoxy-7α-hydroxygedunin potassium salt. The 7-deacetoxy-7α-hydroxygedunin was obtained in 88% w/w yield as a fluffy white precipitate by recrystallization from methanol. The 7-deacetoxy-7α-hydroxygedunin and the starting material were evaluated for antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae using the microbroth dilution assay. It was discovered that 7-deacetoxy-7α-hydroxygedunin potassium salt had minimum inhibitory concentration (MIC) of 1000 µg/ml against K. pneumoniae, 2000 µg/ml against S. aureus, and E. coli. However, B. subtilis was not susceptible to 7-deacetoxy-7α-hydroxygedunin potassium salt at 2000 µg/ml. Interestingly, 7-deacetoxy-7α-hydroxygedunin had MIC of 2000 µg/ml against B. subtilis, and E. coli; and MIC of 1000 µg/ml against K. pneumoniae.

A Systemic review on Antioxidant Potential of Berries used in Imuuxanth by Renatus

“…The absorbance rate varies depending on the type of acid, with chlorogenic acid being inadequately absorbed, and gallic acid fleetly absorbed. Ellagic acid represents about 50 of the total phenolic composites in cranberries and snorts 16 . In addition, both berries rich in resveratrol, which belongs to the group of stilbenes?…”