Synthesis and Antibacterial Activity of Chalcones and Pyrimidine‐2‐ones

Parekh, A. K.; Desai, K. K.

doi:10.1155/2005/134830

Cited by 4 publications

(4 citation statements)

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“…For the synthesis of the two chalcones, a Claisen-Schmidt condensation reaction under basic conditions between 2-acetylpyridine A1 or 2-acetyl-6-methylpyridine A2 and aldehyde A3 was carried out (See Scheme 1 ) [ 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

et al. 2022

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This work is devoted to the study of two copper complexes (Cu) bearing pyridine ligands, which were synthesized, evaluated and tested as new visible light photoinitiators for the free radical photopolymerization (FRP) of acrylates functional groups in thick and thin samples upon light-emitting diodes (LED) at 405 and 455 nm irradiation. These latter wavelengths are considered to be safe to produce polymer materials. The photoinitiation abilities of these organometallic compounds were evaluated in combination with an iodonium (Iod) salt and/or amine (e.g., N-phenylglycine—NPG). Interestingly, high final conversions and high polymerization rates were obtained for both compounds using two and three-component photoinitiating systems (Cu1 (or Cu2)/Iodonium salt (Iod) (0.1%/1% w/w) and Cu1 (or Cu2)/Iod/amine (0.1%/1%/1% w/w/w)). The new proposed copper complexes were also used for direct laser write experiments involving a laser diode at 405 nm, and for the photocomposite synthesis with glass fibers using a UV-conveyor at 395 nm. To explain the obtained polymerization results, different methods and characterization techniques were used: steady-state photolysis, real-time Fourier transform infrared spectroscopy (RT-FTIR), emission spectroscopy and cyclic voltammetry.

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Section: Resultsmentioning

confidence: 99%

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

et al. 2022

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“…[158][159][160] Chalcones are bioinspired photoinitiators and can be prepared in one step, by a Claisen Schmidt condensation of an aldehyde and an acetophenone. [161][162][163][164][165][166][167] Especially, this condensation can be carried out in green conditions, most of the time in ethanol and by using an aqueous solution of KOH or NaOH as the base. To end, the workup is often limited to a simple filtration, the chalcone precipitating in ethanol.…”

Section: Chalconesmentioning

confidence: 99%

Recent advances on photobleachable visible light photoinitiators of polymerization

Dumur

2023

European Polymer Journal

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“…Thiosemicarbazones represent a class of organic substances which in many cases manifest biological properties such as antibacterial [3], antifungal [4], antiviral [5], and antimalarial [6]. The complexes of thiosemicarbazones with metal ions may be considered as the potential biological agents.…”

Section: Introductionmentioning

confidence: 99%

Copper(II) coordination compounds with 2-acetylpyridine N4-(bicyclo[2.2.1]heptan-2-yl)thiosemicarbazone as potential antibacterial agents

Graur,

Gulea

et al. 2023

Studia MSU. St.Nat.

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The paper presents the synthesis of the new 2-acetylpyridine N4-(bicyclo[2.2.1]hept-2-yl)thiosemicarbazone (HL) and its three copper(II) coordination compounds: [Cu(L)X] (X = NO3 - (I), Cl- (II), CHCl2COO- (III)). The obtained compounds were studied by NMR and FTIR spectroscopies, elemental analysis, and molar electric conductibility. The antibacterial activity towards Gram-positive (Staphylococcus aureus, Bacillus cereus) and Gram-negative (Escherichia coli, Acinetobacter baumannii) standard strains was studied for the HL and complexes I-III. The coordination of the HL to the copper(II) atom leads to the increase of activity against almost all microorganisms. Complex I is the most active one towards Gram-positive microorganisms, while complex III is the most active one towards Gram-negative microorganisms. They in many cases surpass the activity of Furacillinum and are practically on the same level as Tetracycline towards Gram-positive microorganisms.

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Synthesis and Antibacterial Activity of Chalcones and Pyrimidine‐2‐ones

Abstract: Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and

Cited by 4 publications

References 1 publication

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Recent advances on photobleachable visible light photoinitiators of polymerization

Copper(II) coordination compounds with 2-acetylpyridine N4-(bicyclo[2.2.1]heptan-2-yl)thiosemicarbazone as potential antibacterial agents

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