Synthesis and Antibacterial Activity of New Acridone Derivatives Containing an Isoxazoline Fragment

Kudryavtseva, T. N.; Lamanov, A. Yu.; Sysoev, P. I.; Климова, Л. Г.

doi:10.1134/s1070363220010077

Cited by 6 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of particular note, compounds 41a , and 41b showed the highest activity against C. albicans . Antibacterial activity was enhanced by the presence of nitrofuran on the isoxazoline ring [ 65 ].…”

Section: Biological Effects Of Natural Products Containing the Isoxaz...mentioning

confidence: 99%

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Wang

Tang

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.

show abstract

Section: Biological Effects Of Natural Products Containing the Isoxaz...mentioning

confidence: 99%

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Wang

Tang

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Compounds 69 and 70 were found to be potent against C. albicans with significant zones of growth inhibition of 43.1±1.0 and 49.1±1.0 mm, as compared with the reference drugs furacilin and ofloxacin (Figure 14). [140] Gaonkar et al. explored a series of 3‐[5‐ethyl‐2‐(2‐phenoxyethyl)pyridin]‐5‐substituted isoxazolines to obtain new heterocyclic compounds containing a pyridine moiety.…”

Section: Pharmacological Profile Of Isoxazoline Derivativesmentioning

confidence: 99%

2‐Isoxazolines: A Synthetic and Medicinal Overview

Kumar

Shankar

2020

ChemMedChem

View full text Add to dashboard Cite

Isoxazolines are nitrogen‐ and oxygen‐containing five‐membered heterocyclic scaffolds with extensive biological activities. This framework can be readily obtained in good to excellent yields through 1,3‐dipolar cycloaddition between nitrones with alkynes or allenes, aryl/alkyl halides, alkynes, and oxaziridines under mild conditions. This scaffold has been an emerging area of interest for many researchers given their wide range of bioactivities. Herein we review synthetic strategies toward isoxazolines and the role these efforts have had in enhancing the biological activity of natural products and synthetic compounds such as antitubercular agents, COX‐1 inhibitors, COX‐2 inhibitors (e. g., valdecoxib), nicotinic receptor modulators, and MIF inhibitors. With a focus on efforts from 2010 onward, this review provides in‐depth coverage of the design and biological evaluation of isoxazoline systems and their impact on various pathologies.

show abstract

“…Compounds bearing an isoxazoline moiety are considered a significant class of nitrogen and oxygen atom-containing heterocyclic products, attracting attention from organic and medicinal chemists due to their large spectrum of biological properties such as antibacterial [1,2], antimicrobial [3], anti-inflammatory [4], anticancer [5,6], antidiabetic [7] and anti-Alzheimer effects [8]. Moreover, isoxazoline derivatives are also known by their agrochemical properties as herbicidal [9], insecticidal [10][11][12] and acaricidal agents [13].…”

Section: Introductionmentioning

confidence: 99%

(3-(4-Chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl Benzenesulfonate

Mokhi,

Chkirate,

Zhang

et al. 2023

Molbank

View full text Add to dashboard Cite

A novel single crystal of (3-(4-chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl benzenesulfonate has been synthetized via a one-pot sequential strategy under sonication. The single crystal has been investigated using X-ray diffraction analysis. Hydrogen bonding between C–H···O and C–H···N produces a layer structure in the crystal. According to a Hirshfeld surface analysis, interactions H···H (28.9%), H···O/O···H (26.7%) and H···C/C···H (15.8%) make the largest contributions to crystal packing. The optimized structure and the solid-state structure that was obtained through experiments are compared using density functional theory at the B3LYP/6-311 G + (d,p) level. The computed energy difference between the lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO) is 4.6548 eV.

show abstract

Synthesis and Antibacterial Activity of New Acridone Derivatives Containing an Isoxazoline Fragment

Cited by 6 publications

References 7 publications

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

2‐Isoxazolines: A Synthetic and Medicinal Overview

(3-(4-Chlorophenyl)-4,5-dihydroisoxazol-5-yl)methyl Benzenesulfonate

Contact Info

Product

Resources

About