Synthesis and antibacterial activity of substituted quinoxaline N-oxides with methyl or methoxy substituents in the benzene ring

Musatova, I. S.; Elina, A. S.; Trifonova, Evgeniya A.; Padeiskaya, E. N.; Novitskaya, N. A.; Ul'yanova, T. N.

doi:10.1007/bf00789527

Cited by 1 publication

(1 citation statement)

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“…The more active the chemical, the less negative the reduction potential is a well‐grounded statement for those compounds that have shown promising biological action in which chlorine atom substituted on 6th and 7th position of the heterocyclic ring with substitution of 2‐phenylethyl on CONH 2 exhibited highly potent activity (Torres et al, 2011). Musatova et al experimentally discovered that QdNOs containing dimethyl ( 14 ; Figure 3), methyl, acetoxymethyl, or hydroxymethyl ( 15 ; Figure 3) groups in positions 2 or 2,3 exhibit significant antibacterial action (Musatova et al, 1979).…”

Section: Biological Activitiesmentioning

confidence: 99%

An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold

Agrawal

Bhardwaj

2022

Chem Biol Drug Des

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Quinoxaline 1,4‐di‐N‐oxides (QdNOs) exhibit multifaceted biological properties, wherein antimicrobial, anticancer, antitrypanosomal, and anti‐inflammatory properties are included. Because of their various activities in clinical practice and research, they have a wide spectrum of uses and possibilities. QdNOs have received a significant amount of attention, and research into their medicinal chemistry is still a part of experimental investigation and analytical studies. In this review, QdNOs are classified depending on their actions, which include antibacterial and anti‐mycobacterial, anticancer or antitumor, antimalarial, antifungal, and other activities. In a conclusion, it's important to base the development of novel synthetic techniques and the design of new QdNO derivatives on the most up‐to‐date knowledge gleaned from recent research. With the summarised structure–activity relationship of fascinating QdNOs, this review aims to provide insights into the developments in the chemistry and biological activity of QdNO derivatives.

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Section: Biological Activitiesmentioning

confidence: 99%