Synthesis and antibacterial activity of benzyl-[3-(benzylamino-methyl)-cyclohexylmethyl]-amine derivatives

Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis

“…7,8 SQ109 is an important drug currently in phase II clinical trial for the treatment of tuberculosis. [9][10][11][12][13] In the attempts to synthesize new antimicrobial agents, [14][15][16] we reported antimicrobial activity of various series of cyclohexane diamine derivatives [17][18][19][20][21] and in continuation with our efforts herein we report the synthesis and antimicrobial activity of another series of novel cyclohexane diamine derivatives (Fig. 1).…”

Antituberculosis Drug Research: A Critical Overview

“…Recently, we have initiated a program toward the development of novel antimicrobial agents, among these cyclohexane‐1,2‐diamine ( 146a‐146t ) and cyclohexane‐1,3‐diyldimethanamine based compounds ( 147a‐147l ) have shown potent antibacterial and antifungal activities with low nano molar MIC values . Interestingly, all these compounds did not show any toxicity even at very high concentration.…”

Synthesis and anticancer activity evaluation of resveratrol–chalcone conjugates

“…49 Using this approach, several research groups have recently reported hybrid molecules by coupling resveratrol with other biologically active molecules such as coumarins, chalcones, curcumin, etc. [50][51][52] In continuation of our research program towards the synthesis of novel bioactive molecules, [53][54][55][56][57][58][59][60][61][62][63][64] we designed and synthesized a series of resveratrol-chalcone conjugates and evaluated their anticancer activity. Herein, we present the results of our investigation.…”