Synthesis and Antibacterial Activity of Isatin Schiff Base Derivative with 3-Aminoacetophenone and its Ni(II), Co(II) Transition Metals Complexes

Alsalihi, Eman I.; Al-Fahdawi, Aeed S.

doi:10.14500/aro.10245

Cited by 7 publications

(1 citation statement)

References 17 publications

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“…Group 6: burn treated with ointment for Staphylococcus aureus each (concentration 50 mg/mL) consisting of 0.5 g of Zn-complex added to 9.5 g of Vaseline.Group 7: burn treated with ointment for each bacteria (concentration 50 mg/mL) consisting of 0.5 g of Zn-complex added to 9.5 g of Vaseline. The treatment continued twice each day during 15 consecutive days and the numbers of bacteria was calculated [20,21].…”

Section: Inhibitory Effect Of Both Compounds On Staphylococcus Aureus and Salmonella Typhi (In Vivo)mentioning

confidence: 99%

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Al-Fahdawi

Al-Sorchee

Saleh³

et al. 2021

Egypt. J. Chem.

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In this research, the synthesis and biological activity evaluation of N, N`-(ethane-1,2-diyl)bis(1-phenyl methanimine) as Schiff base with Zinc (II) dithiocarbamate complex are successfully reported. The suggested geometry around zinc ion centre was determined using selected unique physicochemical and spectroscopic techniques. These include melting point, conductance, FTIR, UV-Vis, mass spectroscopy and 1 H-NMR spectroscopy. The analytical as well as the spectroscopic characterization data proves the formation of zinc complex with general formula [Zn(L)]2 and the complex of this ion is adopting tetrahedral geometry about the metal centre. Furthermore, the present study was carried out to evaluate antibacterial activity of obtained Schiff base ligand and Zn complex against five strains of bacteria (Staphylococcus aureus, Escherichia coli, Lacto bacillus, Klebsiella Pneumonae,and Salmonella typhi). The results of antimicrobial screening suggest that Schiff bases can show a considerable activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Salmonella typhi while Zn-complex was reported to be more active against all bacterial strains which is used in this test. The antibacterial activity of each compound has been examined practically (in vivo) by treating burns rats infected with tested bacteria (Staphylococcus aureus and Salmonella typhi), the results have shown signs of good recovery at short time if it compared with antibiotic Ofloxacin (OFX) used at the same time. And the number of bacteria was reduced significantly (P ≤ 0.001) during the treatment days. Furthermore, the results showed that Zn-complex is effective in treating various skin conditions; it is preferable to use it in the treatment of pathological injuries and against other skin infections.

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Section: Inhibitory Effect Of Both Compounds On Staphylococcus Aureus and Salmonella Typhi (In Vivo)mentioning

confidence: 99%

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Al-Fahdawi

Al-Sorchee

Saleh³

et al. 2021

Egypt. J. Chem.

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Synthesis and characterization of pectin-xanthate and their application in heavy metal and lignin enriched paper industry wastewater treatment

Chaurasiya,

Pande,

Shankar

et al. 2023

Separation Science and Technology

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Synthesis and Characterization of new Manganese(II), Cobalt(II), Cadmium(II) and Mercury(II) Complexes with ligand [N-(3-acetylphenylcarbamothioyl)-2-chloroacetamide] and their Antibacterial Studies

Waheed¹,

Hameed

2019

J. Phys.: Conf. Ser.

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Addition chloro acetyl isothiocyanate (C3H2ClNOS) with 3-Aminoaceto phenone (C8H9NO) to prepare a fresh Ligand [N-(3-acetyl phenyl carbamothioyl)-2-chloroacetamide](L). The ligand (L) behaves as bidentate coordinating through O and S donor with metal ions, the general formula of all complexes [M(L)2(Cl)2](M+2 = Manganese(II), Cobalt(II), Cadmium(II) and Mercury(II)). Compounds were investigation by Proton-1, Carbon -13 NMR spectra (ligand (L) only), Element Microanalysis for C, N, H, O, S, Fourier-transform infrared, UV visible, Conductance, Magnetic susceptibility and Atomic Absorption (A.A). Based on spectral data, complexes appear octahedral geometry. The anti-bacterial activity of the complexes against two type of bacterial was higher than for free ligand.

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Synthesis and Antibacterial Activity of Isatin Schiff Base Derivative with 3-Aminoacetophenone and its Ni(II), Co(II) Transition Metals Complexes

Abstract: Abstract-The (E)-

Cited by 7 publications

References 17 publications

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Synthesis and study of N, N` -(ethane-1,2-diyl)bis(1-phenyl methanimine) and thier complex derivative with in-vivo and in-vitro Bacteryal biological study

Synthesis and characterization of pectin-xanthate and their application in heavy metal and lignin enriched paper industry wastewater treatment

Synthesis and Characterization of new Manganese(II), Cobalt(II), Cadmium(II) and Mercury(II) Complexes with ligand [N-(3-acetylphenylcarbamothioyl)-2-chloroacetamide] and their Antibacterial Studies

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