Synthesis and Antibacterial Activity of 1β-Methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and Related Compounds

Oh, Chang Hyun; Cho, Han Won; Lee, In Kyu; Gong, Jai Yang; Choi, Joung Hoon; Cho, Jung Hyuck

doi:10.1002/1521-4184(200204)335:4<152::aid-ardp152>3.0.co;2-b

Cited by 15 publications

(1 citation statement)

References 4 publications

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“…5,6 The carbapenem compounds having (3S)-pyrrolidin-3-ylthio group at the C-2 position in the carbapenem skeleton are noted for their broad and potent antibacterial activity, 7 and therefore a large number of these derivatives have been synthesized and investigated. [8][9][10][11][12] At present, several carbapenem derivatives such as S-4661, 13 BO-2727 14 and E-1010 15 are under clinical or preclinical studies since the launch of meropenem.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

2008

Bulletin of the Korean Chemical Society

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The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5-azaspiro [2,4]heptane moiety showed the most potent antibacterial activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

2008

Bulletin of the Korean Chemical Society

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Synthesis and Antibacterial Activities of 4‐Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain

Cho

Lee

et al. 2003

Archiv der Pharmazie

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The synthesis of a new series of 2-alkyl-4-pyrrolidinylthio-b-methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds (14 b, 14 c) containing 3-methyl- and 3, 5-dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity.

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Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted Imidazolino Pyrrolidin‐3‐ylthio)carbapenem Derivatives

Oh¹,

Lee²,

Lee³

et al. 2003

Archiv der Pharmazie

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The synthesis of a new series of 1 beta-methylcarbapenems containing a substituted imidazolino pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the imidazoline ring was investigated. Compound 13 g which has a N-sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity.

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Synthesis and Antibacterial Activity of 1β-Methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and Related Compounds

Cited by 15 publications

References 4 publications

Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

Synthesis and Antibacterial Activities of 4‐Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain

Synthesis and Antibacterial Activity of 1β‐Methyl‐2‐(5‐substituted Imidazolino Pyrrolidin‐3‐ylthio)carbapenem Derivatives

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