Synthesis and antibacterial activity of 3,4-dihyhdropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-ones

Abstract

A series of 3,4-dihydropyrido [3',2':4,5]thieno[3,2-d]pyrimidin-4-ones were synthesized by the reaction of ethyl 3-alkyl(aryl)carboxamidothieno[2,3-b]pyridine-2-carboxylates with aliphatic amines. The starting carboxamides were obtained via the reaction of ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate with acid chlorides. It is established that the synthesized pyridothienopyrimidinones possess antistaphylococcal activity. 533 0091-150X/08/4209-0533

Synthesis of some new thienopyridine and pyridothienopyrimidine derivatives with expected antitumor activity

“…In the last several decades, pyridothienopyrimidine derivatives have received considerable attention due to their wide-range of applications.Pyridothienopyrimidines are reported to exhibit anticancer [1][2][3], anti-inflammatory [4,5] antimalarial [6], anti-allergy [7], anti-microbial [8][9], antifilarial [10]. Insecticidal activities [11], also as V.E.…”