Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles

Tiwari, Rakesh; Singh, Devender; Singh, Jaspal; Yadav, Vipul; Pathak, Ajay K.; Dabur, Rajesh; Chhillar, Anil Kumar; Singh, Rambir; Sharma, Gainda L.; Chandra, Ramesh; Verma, Akhilesh K.

doi:10.1016/j.bmcl.2005.09.066

Cited by 69 publications

(28 citation statements)

References 19 publications

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“…Various methods [12][13][14][15] are available for the evaluation of the antibacterial activity of different types of drugs. However, the most widely used method [15] in determining the antibacterial activity of the drug is to add it in known concentrations to cultures of the test organisms.…”

Section: In Vitro Antibacterial Activitymentioning

confidence: 99%

Platinum(IV) and palladium(II) thiosemicarbazide and thiodiamine complexes: A spectral and antibacterial study

Mishra

Manav

et al. 2007

Journal of Coordination Chemistry

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Platinum(IV) and palladium(II) complexes [Pt(L) 2 Cl 2 ] and [Pd(L)Cl 2 ], [where, L ¼ 1,1-diphenyl-2-thiosemicarbazide (L 1 ) and (1,1-diphenyl-2-thio)-1,3-propanediamine (L 2 ) have been synthesized. The thiosemicarbazides and thiodiamines exist as the thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands are monobasic bidentate. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial studies have also been carried out for some complexes.

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Section: In Vitro Antibacterial Activitymentioning

confidence: 99%

Platinum(IV) and palladium(II) thiosemicarbazide and thiodiamine complexes: A spectral and antibacterial study

Mishra

Manav

et al. 2007

Journal of Coordination Chemistry

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“…On the other hand, indole derivatives have been a topic of substantial research interest in contemporary heterocyclic and medicinal chemistry due to their great significance in the view of their (i) occurrence in nature as a prominent sub-structure of a large number of alkaloids (Tanaka et al, 2006;Frederich et al, 2008) and (ii) wide-ranging biological activities which includes antimicrobial (Al-Qawasmeh et al, 2010;Tiwari et al, 2006;Harnden et al, 1978), antitubercular (Karthikeyan et al, 2009;Guzel et al, 2008), ghrelin receptor (Demange et al, 2007), anticancer (Singh et al, 2009;Shi et al, 2007), antioxidant (Lakshmi et al, 2010), antiviral (Giampieri et al, 2009;Fonseca et al, 2004), and antimalarial (Kgokong et al, 2005;Agarwal et al, 2005). Literature survey manifests that the number of 4H-chromene derivatives have been synthesized using various aldehydes Patel, 2009a, 2011b;Mungra et al, 2011b) but there is not a single report where 2-phenyl-1H-indole-3-carbaldehyde is used.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

Kathrotiya

Patel

2011

Med Chem Res

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A new series of indole-based chromene derivatives 4a-4p has been synthesized by one pot cyclocondensation reaction of 2-phenyl-1H-indole-3-carbaldehyde 1a-1h; malononitrile 2; and 1,3-cyclohexanedione/dimedone 3a/b under microwave irradiation catalyzed by an organocatalyst 4-(N,N-dimethylamino) pyridine. Easy experimental procedure, high yield, selectivity, and shorter reaction time are the imperative features of this method. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than that of standard drugs as evident from SAR study.

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“…bis -Indole-based compounds have been reported to have broad-spectrum antibacterial activities against antibiotic-resistant strains and are currently being pursued as topical agents (Figure 1) [5-7]. 1,2,3,4-Tetrahydropyrazino [1,2] indoles [8] and triazino [[8],6-b] indoles [9] have been reported to have antifungal properties. Hapalindole A isolated from the blue green algae Hapalosiphon fontinalis is a 3-substituted indole derivative.…”

Section: Introductionmentioning

confidence: 99%

Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities

Rao

Jain

et al. 2011

Org Med Chem Lett

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An efficient, one-pot synthesis was developed for 3-aminoalkylated indoles by three-component coupling reaction of aldehydes, N-methylanilines, and indoles using AgOTf as a catalyst. A series of twenty 3-aminoalkylated indoles was evaluated for their antibacterial activities against both Gram negative and Gram positive bacteria. Compounds 4b and 4r showed good antibacterial activity against both Gram positive and Gram negative strains. However, inversing the property of substituent (from 4r to 4q) resulted in the significant fall in the magnitude of antibacterial activity against Escherichia coli.

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Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles

Cited by 69 publications

References 19 publications

Platinum(IV) and palladium(II) thiosemicarbazide and thiodiamine complexes: A spectral and antibacterial study

Platinum(IV) and palladium(II) thiosemicarbazide and thiodiamine complexes: A spectral and antibacterial study

Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity

Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities

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