Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

Bhavanarushi, Sangepu; Kanakaiah, V.; Gandu, Bharath; Gangagnirao, A; Rani, J. Vatsala

doi:10.1007/s00044-013-0623-3

Cited by 35 publications

(17 citation statements)

References 36 publications

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“…Later on the innovation of the natural pyrazole Cglycoside and pyrazofurin ( Figure 1) which established a wide spectrum of antimicrobial activity [18,19] much interest is given to pyrazoles as antimicrobial agents. [24] In Continuation of our study on the activity of pyrazoles against bacteria, [25][26][27] in this work, we would like to report the preparation of a variety of pyrazol-methylene-hydrazide derivatives and their antimicrobial activity study. [24] In Continuation of our study on the activity of pyrazoles against bacteria, [25][26][27] in this work, we would like to report the preparation of a variety of pyrazol-methylene-hydrazide derivatives and their antimicrobial activity study.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, pyrazoles with potential anti-MAO efficacy [20,21] and their analogues which represent inhibitors of Mycobacterium tuberculosis, [22] antitubercular agents, [23] FMS-like tyrosine kinase-3 (FLT3) inhibitors. [24] In Continuation of our study on the activity of pyrazoles against bacteria, [25][26][27] in this work, we would like to report the preparation of a variety of pyrazol-methylene-hydrazide derivatives and their antimicrobial activity study.…”

Section: Introductionmentioning

confidence: 99%

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F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

Bhavanarushi

Luo

Gandu

et al. 2019

Journal of Heterocyclic Chem

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This paper investigates the seismic and collapse performance of shape memory alloy (SMA) braced steel frame structures considering the effects of various brace design parameters and ultimate state of SMAs. An SMA braced steel frame building is designed to have comparable strength and stiffness with a steel-moment resisting frame selected as case study building. Then, the stiffness and ultimate deformation capacity of the SMA braces in the initially designed reference SMA braced frame are systematically varied. First, the static pushover analysis and incremental dynamic analysis (IDA) are employed to illustrate the significance of SMA brace failure consideration in seismic performance assessment of steel frames with SMA elements. Then, the influence of SMA brace initial stiffness and ultimate deformation capacity on the seismic and collapse performance of SMA braced frames are studied through pushover analyses, nonlinear response history analyses, and IDA. The results show that the SMA brace initial stiffness does not affect the interstory drift and floor absolute acceleration response at design and maximum considered earthquake (MCE) level seismic hazard or collapse capacity of the frame. However, it has considerable influence on post-event functionality of the frame. It is also found that the SMA brace ultimate deformation capacity should be at least 80% of maximum inter-story drift demand at MCE level for satisfactory seismic performance, while larger values provide higher collapse capacity for the SMA braced frame.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

Bhavanarushi

Luo

Gandu

et al. 2019

Journal of Heterocyclic Chem

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“…Pyrazoles and their derivatives are an important class of heterocyclic compounds and attractive targets both in the pharmaceutical industry and organic synthesis, as they are the core structure of numerous biologically active compounds . Pyrazoles, especially 1H‐pyrazol‐5(4H)‐one derivatives including 4,4’‐(arylmethylene)bis(1H‐pyrazol‐5‐ol)s have exhibited a wide range of biological activities, such as antipyretic, antidepressant, antibacterial, antiviral, antitumor and antiinflammatory . The conventional method for synthesis of these compounds is by a one‐pot pseudo‐three‐component condensation of aldehydes with two equivalents of 3‐substituted‐5‐pyrazolone which condensed from hydrazines and dialkyl acetylenedicarboxylate/β‐ketoester derivatives .…”

Section: Introductionmentioning

confidence: 99%

A Green and Efficient One‐Pot Pseudo‐Five‐Component Reaction for Synthesis of Bis(pyrazol‐5‐ol) Derivatives via Tandem Cyclocondensation‐Knoevenagel–Michael Reaction

Yang

Liu

2017

ChemistrySelect

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A simple, green and efficient approach for one‐pot pseudo‐five‐component synthesis of the 4,4’‐(arylmethylene)bis(1H‐pyrazol‐5‐ol) derivatives from hydrazines, dialkyl acetylenedicarboxylats/β‐ketoesters and aromatic aldehydes catalyzed by Dabco‐base ionic liquids in aqueous media has been successfully developed. All the reactions were performed under 3 mol% of ionic liquid catalyst, and afforded the corresponding bis(pyrazol‐5‐ol)s in excellent yields (81‐98 %). This method also offers several other notable advantages, such as environmental friendliness, short reaction times, easy workup and reusability of the inexpensive catalyst.

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“…In general, synthesis of 4,4′‐(arylmethylene)bis(3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐ols) is performed under non conventional conditions such as ultrasound irradiation, microwave, and electrolysis and also in catalytic conditions like acetic acid or piperidine , sodium dodecyl sulfate , TEBA , silica bonded S‐sulphonic acid , PEG‐400 at 110°C , CAN , and NH 4 OAc . However, most of these synthetic protocols suffer from some demerits.…”

Section: Introductionmentioning

confidence: 99%

An Organocatalyzed Efficient One‐pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4′‐(Arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ols)

Mahajan

Nikam

Khedkar

et al. 2016

Journal of Heterocyclic Chem

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The synthesis of 4,4′‐(arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ol) derivatives catalyzed by ʟ‐proline is a simple, versatile, and efficient method. In vitro antioxidant, anti‐inflammatory, and antimicrobial activities of compounds 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j were studied. Furthermore, to rationalize the observed anti‐inflammatory activity data, molecular docking study has been performed against COX‐2 enzyme which revealed a good binding affinity for these molecules and could provide an insight into the various bonded and non‐bonded interactions guiding their binding affinity.

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Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

Cited by 35 publications

References 36 publications

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

F(1H‐Pyrazol‐4‐yl)methylene‐Hydrazide derivatives: Synthesis and antimicrobial activity

A Green and Efficient One‐Pot Pseudo‐Five‐Component Reaction for Synthesis of Bis(pyrazol‐5‐ol) Derivatives via Tandem Cyclocondensation‐Knoevenagel–Michael Reaction

An Organocatalyzed Efficient One‐pot Synthesis, Biological Evaluation, and Molecular Docking Studies of 4,4′‐(Arylmethylene)bis‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ols)

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