Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

He, Jun; Tang, Xuemei; Liu, Tingting; Peng, Feng; Zhou, Qing; Liu, Liwei; He, Ming; Xue, Wei

doi:10.1007/s11696-020-01363-3

Cited by 12 publications

(10 citation statements)

References 34 publications

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“…The filtrate was extracted, and the organic phase was collected and was concentrated by a rotary evaporator to obtain intermediate 3 . A previous method − was used to obtain intermediates 4 and 5 .…”

Section: Materials and Methodsmentioning

confidence: 99%

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Peng

Wang

et al. 2021

J. Agric. Food Chem.

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Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects against Xac, Psa, and Xoo. EC 50 data exhibited that A8 (19.7 μg/mL) had better antibacterial activity against Xoo than myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the best in vivo antiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.

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Section: Materials and Methodsmentioning

confidence: 99%

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Peng

Wang

et al. 2021

J. Agric. Food Chem.

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“…Compounds 56 and 57 showed good antibacterial activity against Rs , both with EC 50 values of 4 mg/L. In addition, they may inhibit bacterial growth by changing the bacterial phenotype and resulting in incomplete bacterial surface [69]. The EC 50 values of compound 58 against Xoo , Xac , and Psa were 1.52, 11.1, and 18.9 mg/L, respectively [70].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Research progress of piperazine and morpholine derivatives in the discovery of agricultural chemicals

Zhang

Xing

Zou

et al. 2023

Journal of Heterocyclic Chem

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Piperazine and morpholine are important heterocyclic structures, which are widely used in the discovery of agrochemicals. Piperazine and morpholine rings are often used as active substructures or bridges to design and synthesize new agrochemicals. In the past decade, piperazine and morpholine compounds have made rapid progress in the research and development of new pesticides, especially in the discovery of fungicides and antibacterial agents. In the future, more piperazine and morpholine pesticides may be commercialized. However, there is no comprehensive review on the use of piperazine and morpholine derivatives in the creation of new agrochemicals. Therefore, we systematically reviewed the application of piperazine and morpholine active compounds in the creation of new pesticides in the past 12 years. This paper not only summarizes the biological activities of piperazine and morpholine compounds, but also discusses the structure–activity relationship, physiological and biochemical changes, and mechanism of action. This work aims to provide inspiration and ideas for the discovery of new agrochemicals of piperazine and morpholine.

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“…collected to synthesize intermediates 3 and 4 through the methods of predecessors. [41,42] General Procedure for the Synthesis of Title Compounds E1-E20 Intermediate 2 (2.2 mmol), K 2 CO 3 (2.4 mmol) and 25 mL acetonitrile were sequentially added to a reaction flask. After the reaction flask was stirred for 10 min, intermediate 4 (2 mmol) was added.…”

Section: Chemistry General Procedures For the Synthesis Of Intermedia...mentioning

confidence: 99%

Antiviral Activities of Novel Myricetin Derivatives Containing 1,3,4‐Oxadiazole Bisthioether

Peng

Liu

Cao

et al. 2022

Chemistry & Biodiversity

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A class of novel myricetin derivatives containing 1,3,4-oxadiazole bisthioether were synthesized. The results of antiviral biological activity demonstrated that the partially compounds exhibited good antiviral effects against tobacco mosaic virus. The in vivo curative and protective activities of compound E12 against TMV was quite significant. The EC 50 value of the curative activity of E12 was 128.8 μg/mL, while the value of ningnanmycin was 296.4 μg/mL. Similarly, the EC 50 value of the protective activity of E12 was 99.1 μg/mL, while the value of ningnanmycin was 307.6 μg/mL. The microscale thermophoresis data indicated that the binding value of ningnanmycin and TMV-CP was 2.726 � 1.301 μM, which was not as good as the binding value of E12 and TMV-CP was 0.029 � 0.013 μM. This study showed that novel myricetin derivatives containing 1,3,4-oxadiazole bisthioether may be a kind of agricultural antiviral drugs with great potential.

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Synthesis and antibacterial activity of novel myricetin derivatives containing sulfonylpiperazine

Cited by 12 publications

References 34 publications

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Research progress of piperazine and morpholine derivatives in the discovery of agricultural chemicals

Antiviral Activities of Novel Myricetin Derivatives Containing 1,3,4‐Oxadiazole Bisthioether

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