Synthesis and Antibacterial Activity of Selenium-functionalized Poly(ε-caprolactone)

Li, Yingying; Xing, Dong; Pan, Xiangqiang; Zhu, Jian

doi:10.1007/s10118-021-2638-4

Cited by 7 publications

(8 citation statements)

References 63 publications

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“…Initial work from our group and others found that polyselenonium salts showed promising antimicrobial properties. , We believe that the antimicrobial properties of polyselenonium salts could be further enhanced by optimizing the structures. Normally, hydrophobic-cationic balance plays a critical role in determining bactericidal activity. , Thus, herein, four selenide-functionalized caprolactone monomers with different substituents were synthesized to optimize the hydrophobic-cationic balance of polyselenonium.…”

mentioning

confidence: 82%

“…The TU2/TBD catalyst was previously used for the polymerization of 7-phenylselenomethyl-2-oxepanone with excellent control according to our previous work. 36 In this work, we still used a binary catalytic system (Figure 1) with PhSeCL as the model monomer to achieve ROP of the monomer. The TU1/DBU catalyst system was the fastest in the binary catalytic system, and a polymer with a narrow molecular weight distribution was achieved (Table S1, entry 6).…”

Section: Nmr (Figures S1−s8)mentioning

confidence: 99%

“…Recently, polyselenonium salts have attracted attention in antibacterial applications, but their antibacterial effect does not meet expectations. 35,36 It is worth noting that most antibacterial polymers reported in the literature are nondegradable, which limits their application in vivo. The design of cationic polymers should therefore preferably be designed to be biodegradable and biocompatible.…”

mentioning

confidence: 99%

“…Initial work from our group and others found that polyselenonium salts showed promising antimicrobial properties. 35,36 We believe that the antimicrobial properties of polyselenonium salts could be further enhanced by optimizing the structures. Normally, hydrophobic-cationic balance plays a critical role in determining bactericidal activity.…”

mentioning

confidence: 99%

“…Selenium exists in the form of selenoprotein and plays an important role in antioxidant, antibacterial, anti-inflammatory, and autoimmune regulation. − Notably, organoselenium compounds possess sensitive redox properties , and biological properties, which have made them a very popular class of biomedical materials, such as drug carriers , and cancer therapeutics. , Selenium cations frequently appear as Lewis acids in catalysis. − However, there are few related studies on polyselenonium salts. Recently, polyselenonium salts have attracted attention in antibacterial applications, but their antibacterial effect does not meet expectations. , …”

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confidence: 99%

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Degradable Selenium-Containing Polymers for Low Cytotoxic Antibacterial Materials

Zhang

et al. 2022

ACS Macro Lett.

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Developing biodegradable cationic polymers with high antibacterial efficiency and low cytotoxicity is of great significance in biological applications. Selenium is an essential trace element for the human body, and selenium-containing compounds are promising in various health-related applications. To combine selenium with biodegradability, selenidefunctionalized polycaprolactones (PCL) with different hydrophobic substituents were synthesized followed by selenoniumization. The optimal polyselenonium salt showed excellent antibacterial activity with an MBC of 2 μg mL −1 and an MIC of 1 μg mL −1 and exhibited good biocompatibility before and after degradation. In addition, the obtained selenium polymer can be well blended with commercial PCL by electrospinning, and films with good antibacterial activity were prepared. This work enriches the knowledge of selenium derivatives and lays a foundation for follow-up research on selenium cationic polymers in the antimicrobial field.

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mentioning

confidence: 82%

Section: Nmr (Figures S1−s8)mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Degradable Selenium-Containing Polymers for Low Cytotoxic Antibacterial Materials

Zhang

et al. 2022

ACS Macro Lett.

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Thermally Responsive Selenide‐containing Materials Based on Transalkylation of Selenonium Salts

Chen,

Scholiers,

Zhang

et al. 2023

Angewandte Chemie

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Covalent adaptable networks (CANs) possess unique properties as a result of their internal dynamic bonds, such as self‐healing and reprocessing abilities. In this study, we report a thermally responsive C‐Se dynamic covalent chemistry (DCC) that relies on the transalkylation exchange between selenonium salts and selenides, which undergo a fast transalkylation reaction in the absence of any catalyst. Additionally, we demonstrate the presence of a dissociative mechanism in the absence of selenide groups. After incorporation of this DCC into selenide‐containing polymer materials, it was observed that the cross‐linked networks display varying dynamic exchange rates when using different alkylation reagents, suggesting that the reprocessing capacity of selenide‐containing materials can be regulated. Also, by incorporating selenonium salts into polymer materials, we observed that the materials exhibited good healing ability at elevated temperatures as well as excellent solvent resistance at ambient temperature. This novel dynamic covalent chemistry thus provides a straightforward method for the healing and reprocessing of selenide‐containing materials.

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Thermally Responsive Selenide‐containing Materials Based on Transalkylation of Selenonium Salts

Chen,

Scholiers,

Zhang

et al. 2023

Angew Chem Int Ed

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Synthesis and Antibacterial Activity of Selenium-functionalized Poly(ε-caprolactone)

Cited by 7 publications

References 63 publications

Degradable Selenium-Containing Polymers for Low Cytotoxic Antibacterial Materials

Degradable Selenium-Containing Polymers for Low Cytotoxic Antibacterial Materials

Thermally Responsive Selenide‐containing Materials Based on Transalkylation of Selenonium Salts

Thermally Responsive Selenide‐containing Materials Based on Transalkylation of Selenonium Salts

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