Synthesis and Antibacterial Evaluation of Ciprofloxacin Congeners with Spirocyclic Amine Periphery

Lukin, Alexey; Komarova, Kristina; Vinogradova, Lyubov; Rogacheva, Elizaveta; Краева, Л. А.; Krasavin, Mikhail

doi:10.3390/ijms24020954

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Ciprofloxacin has 12 FDA-approved human uses and other veterinary uses, but it is often used for unapproved uses (off-label). Ciprofloxacin interacts with other drugs, herbal and natural supplements, and thyroid medications (Lukin et al, 2023). Ciprofloxacin is a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria.…”

Section: Discussionmentioning

confidence: 99%

Study the Effect of Ciprofloxacin and Diclofenac Combination Treating Urinary Tract Infection by Resistance E.coli 0157:H7 in Female Rabbits

R Kbyeh,

N. Abedsalih

2023

AAVS

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This study is designed to highlight some of the anti-bacterial effect for diclofenac aganist resist. E .coli 0157: H7, as well as the ability of the diclofenac represented by anti-inflammatory and ciprofloxacin combat the exposure of urinary tract infection. The virulence components responsible for colonization and penetration also have a role in the pathogenicity of the resistant Escherichia coli 0157: H7 strain. Resistance Escherichia coli 0157 H7 for antibiotics decreases the cure rate. Repurposing Food and Drug Administration (FDA) approved medications against the contributing factors is a novel method to overcome this scarcity. The analgesic medication diclofenac was reported to have anti-virulence action against resistance Escherichia coli O157 :H7. This study aimed to demonstrate the antimicrobial effect of diclofenac, Ciprofloxacin, and a combination (diclofenac +ciprofloxacin) against clinical resistance E coli o157 H7 isolates by using Polymerase chain reaction (PCR). The presented study, all rabbits, forty-eighth adult female rabbit aged (6-8 weeks) and weighing between (1500 and 2000) gm., was randomly divided into six equal groups(8/each) groups injection 0.1 ml in 1 x 10 9 CFU Escherichia coli 0157: H7 by urinary catheterization route excepting in negative control and all groups resulted in a significant increase in urea creatinine, sodium, Potassium, chloride concentration in the blood after three days comparison with negative control and in all experimental period (14 days) which was no significant change (P < 0.05) between positive control (PC) and diclofenac treated groups but combination (ciprofloxacin 3.5 mg/kg+diclofenac1mg/kg) COM1 group and combination (ciprofloxacin 1.75 mg/kg+diclofenac1mg/kg) com2 significant decrease (P< 0.05) after (seven, fourteen) days comparison with positive control ,diclofenac group was used in combination with antibiotics as the anti-virulence agent which was enhance the ability of the immune system to eradicate infection. Altogether, we can conclude that the diclofenac has the required anti-boiflim effects to support ciprofloxacin effect and the body responses against urinary tract infection consequences of E coli O157 :H7

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Section: Discussionmentioning

confidence: 99%

Study the Effect of Ciprofloxacin and Diclofenac Combination Treating Urinary Tract Infection by Resistance E.coli 0157:H7 in Female Rabbits

R Kbyeh,

N. Abedsalih

2023

AAVS

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Section: Advances Inmentioning

confidence: 99%

Antibacterial Effect of Co-Administration of Diclofenac and Ciprofloxacin against Infection Induced by Resistance E coli (O157-H7) in Female Rabbits

Razzaq Kbyeh,

N. Abedsalih

2023

AAVS

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U rinary tract infections (UTI) are one of the most common medical complications during pregnancy (Kim and Lee, 2023). These infections are characterized by the presence of microorganisms in the genitourinary tract that cannot be explained by contamination, and have the potential to invade the tissues of the urinary tract and adjacent structures. Actually, the term UTI represents a wide variety of conditions, including asymptomatic bac-

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“…On the other hand, thiazole and thiadiazole derivatives constitute crucial frameworks in the realm of medicinal chemistry. An exploration of the literature highlights their significant role encompassing a diverse array of biological effects [44][45][46][47][48], notably including antimicrobial properties [49][50][51][52][53].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Molecular Docking Study of Some New Thiazoles Using Terephthalohydrazide Chitosan Hydrogel as Ecofriendly Biopolymeric Catalyst

Al-Humaidi,

Gomha,

El-Ghany

et al. 2023

Catalysts

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Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole derivatives. Thus, TCs was used as a promising ecofriendly basic biocatalyst for preparation of three new series of thiazoles and two thiadiazoles derivatives via reacting 2-(2-oxo-1,2-diphenylethylidene) hydrazine-1-carbothio-amide with various hydrazonoyl chlorides and α-haloketones under mild ultrasonic irradiation. Also, their yield% was estimated using chitosan and TCs in a comparative study. The procedure being employed has the advantages of mild reaction conditions, quick reaction durations, and high reaction yields. It also benefits from the catalyst’s capacity to be reused several times without significantly losing potency. The chemical structures of the newly prepared compounds were confirmed by IR, MS, and 1H-NMR. Docking analyses of the synthesized compounds’ binding modes revealed promising binding scores against the various amino acids of the selected protein (PDB Code—1JIJ). SwissADME’s online tool is then used to analyze the physiochemical and pharmacokinetic characteristics of the most significant substances. The majority of novel compounds showed zero violation from Lipinski’s rule (Ro5).

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Synthesis and Antibacterial Evaluation of Ciprofloxacin Congeners with Spirocyclic Amine Periphery

Cited by 4 publications

References 28 publications

Study the Effect of Ciprofloxacin and Diclofenac Combination Treating Urinary Tract Infection by Resistance E.coli 0157:H7 in Female Rabbits

Study the Effect of Ciprofloxacin and Diclofenac Combination Treating Urinary Tract Infection by Resistance E.coli 0157:H7 in Female Rabbits

Antibacterial Effect of Co-Administration of Diclofenac and Ciprofloxacin against Infection Induced by Resistance E coli (O157-H7) in Female Rabbits

Green Synthesis and Molecular Docking Study of Some New Thiazoles Using Terephthalohydrazide Chitosan Hydrogel as Ecofriendly Biopolymeric Catalyst

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