Synthesis and Antibacterial Evaluation of Novel Small-Molecule Antibacterials of a Reduced Acridine Structure in S. aureus Strains Including MRSA
Peter Werner,
David Kreutzer,
Nikoletta Szemeredi
et al.
Abstract:Background:
The increasing antibacterial drug resistance remains a threat to global
health with increasing mortality and morbidity. There is an urgent need to find novel antibacterials
and develop alternative strategies to combat the increasing antibacterial drug resistance.
Objective:
We aimed to synthesize novel small-molecule antibacterials to evaluate the structuredependent antibacterial compound activities against S. aureus and MRSA.
Method:
Compounds were synthesized by primary N-alkylation to form a… Show more
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