Synthesis and antibacterial evaluation of novel cationic chalcone derivatives possessing broad spectrum antibacterial activity

1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation

“…Finally, any colonies that formed were counted, and CFU per mL was calculated. All experiments were performed in triplicate [24].…”

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies

“…lack of membrane selectivity), high manufacturing costs and their susceptibility to protease metabolism [9,[12][13]. Recent developments in small molecular AMP mimics aim to eliminate these limitations [12][13][14][15][16][17][18][19][20][21]. One successful example is LTX-109, a three-residue AMP mimic by Lytix Biopharma that has completed Phase 2 clinical trials as a topical agent for nasal decolonization of MRSA [22][23].…”

Methoxy‐Substituted Hydroxychalcone Reduces Biofilm Production, Adhesion and Surface Motility of Acinetobacter baumannii by Inhibiting ompA Gene Expression

“…So far, myriad of chalcone structures have displayed efficient antibacterial activities against both Grampositive and Gram-negative species (aerobic or anaerobic), Mycobacterium tuberculosis, and other resilient genera. [29,31] Besides the substantially efficient growth inhibition activities, with MICs reaching the values below 1 μg ml À 1 in some cases, [32,33] several antivirulence properties of chalcones have also been documented, including the inhibition of biofilm formation, glycocalyx production, motility, and adhesion, [30,34,35] the quorum-quenching activity, [36] inhibition of certain genes' expression and bacterial toxin production, [37] and inhibition of the efflux pumps. [38][39][40] Biofilm formation in A. baumannii is responsible for colonization of abiotic and biotic surfaces, including medical devices and host tissues, thus enabling the persistence and spreading of infection in hospital settings.…”