Synthesis and Antibacterial Study of Some Schiff Bases Complexes

Ambhure, Ram U.; Mirgane, Sunil R.; Thombal, Devidas U.; Nawale, Rajesh B.; Marathe, Rajendra; Pawar, Rajendra P.

doi:10.22606/mocr.2017.21003

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Antibacterial activity [17][18] The individual bacterial inoculums were uniformly spread using sterile cotton swab on solidified nutrient agar medium in different sterile petri plates. Three cups of 8 mm diameter were made in each petri plate using a sterile borer.…”

Section: Assay Of Nitric Oxide Radical Scavengingmentioning

confidence: 99%

Synthesis of Novel 5-Aminosalicylic Acid Schiff Bases by Grinding Method: Evaluation for in Vitro Antioxidant and Antibacterial Activities

Kuchana¹,

Telu²

2018

Int. Res. J. Pharm.

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Grinding technique as a method employing green chemistry was selected for the synthesis of Schiff bases from 5-aminosalicylic acid and substituted benzaldehydes. Two known and eight novel 5-aminosalicylic acid Schiff bases were synthesized and recrystallized using methanol. All the compounds were characterized by their physical data and spectral studies such as IR, 1 H NMR, 13 C NMR and Mass. The synthesized compounds were evaluated for in vitro antioxidant activity by scavenging 1,1-diphenyl-2picrylhydrazyl (DPPH) and nitric oxide free radicals at 100μM concentration. The activity data revealed that the compounds with 4-hydroxy-3,5-dimethoxy substitution and 3,4-methylenedioxy substitution on N-benzylidene ring showed highest antioxidant activity in DPPH and nitric oxide scavenging models respectively. The activity of these compounds was found to be greater than 5-aminosalicylic acid and the standards employed. All the compounds were evaluated for antibacterial activity by agar well diffusion method using gram negative and gram positive bacteria such as E. coli, P. aeruginosa, S. aureus and B. subtilis. The results indicate that the evaluated compounds showed good to moderate antibacterial activity.

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Section: Assay Of Nitric Oxide Radical Scavengingmentioning

confidence: 99%

Synthesis of Novel 5-Aminosalicylic Acid Schiff Bases by Grinding Method: Evaluation for in Vitro Antioxidant and Antibacterial Activities

Kuchana¹,

Telu²

2018

Int. Res. J. Pharm.

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“…They are applicable in medicinal and pharmaceutical fields due to a broad spectrum of biological and analytical activities like anti‐inflammatory, analgesic, antimicrobial, anticonvulsant, antituberculosic, anticancer, antioxidant, anthelmintic, fungicidal, antidepressants, antitumor, nematocide, and anticarcinogenic . Schiff bases are widely used as catalysts and many Schiff base complexes also show excellent catalytic activity in various reactions, and there have been many reports on their applications in homogeneous and heterogeneous catalyses . We used pyridoxal 5′‐phosphate (PLP) and 3‐(aminopropyl)‐triethoxysilane (APTEOS) for the preparation of Schiff base ligand in complexation with transition metal and anchored it into SBA‐15 (Scheme ).…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26][27][28] Schiff bases are widely used as catalysts and many Schiff base complexes also show excellent catalytic activity in various reactions, and there have been many reports on their applications in homogeneous and heterogeneous catalyses. [29][30][31][32][33] We used pyridoxal 5 0 -phosphate (PLP) and 3-(aminopropyl)triethoxysilane (APTEOS) for the preparation of Schiff base ligand in complexation with transition metal and anchored it into SBA-15 (Scheme 1). PLP is water-soluble, naturally present in many foods, and available as a dietary supplement.…”

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confidence: 99%

Synthesis, characterization, and applications of novel Co(II)‐pyridoxalphosphate‐Schiffbase/SBA‐15 as a nanocatalyst for the green synthesis of benzothiazole heterocycles

Yari

Dehkharghani

Bardajee

et al. 2020

J Chinese Chemical Soc

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Mesoporous heterogeneous santa barbara amorphous (SBA)‐15‐supported cobalt complex, as a novel nanocatalyst containing N–O chelating Schiff‐base ligand was successfully synthesized by the reaction of SBA‐15 and Cobalt(II)‐Schiff‐base complex. The Co(II)‐Schiff base complex also was prepared for the first time, by the reaction of pyridoxal 5′‐phosphate or PLP (biological active form of vitamin B6), 3‐(aminopropyl)‐triethoxysilane in methanol that complexation with CoCl2. The subsequent grafting of entitled complex to SBA‐15 afforded Co(II)‐PLP‐Schiff base/SBA‐15 mesoporous catalyst. Characterization of the product was carried out with powder X‐ray diffraction, Brunauer–Emmett–Teller nitrogen adsorption–desorption, transmission electron microscopy, scanning electron microscopy, thermogravimetric analysis, atomic absorption spectroscopy, and inductively coupled plasma, Fourier‐transform infrared spectroscopy. The results revealed the retention of the textural properties and hexagonally uniform structures of SBA‐15 during the grafting procedure. This nanocatalyst was applied successfully for one‐pot synthesis of various benzothiazole heterocycles under green conditions. This catalyst is an active, reusable, and stable nanomaterial with no leaching of metal ions to the reaction medium. It was used for the synthesis of desired benzothiazole heterocycles by the cyclo‐condensation of aryl‐aldehydes with 2‐aminothiophenol with good to excellent yields and under green conditions.

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Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review

Mezgebe,

Mulugeta

2024

Med Chem Res

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Synthesis and Antibacterial Study of Some Schiff Bases Complexes

Cited by 6 publications

References 5 publications

Synthesis of Novel 5-Aminosalicylic Acid Schiff Bases by Grinding Method: Evaluation for in Vitro Antioxidant and Antibacterial Activities

Synthesis of Novel 5-Aminosalicylic Acid Schiff Bases by Grinding Method: Evaluation for in Vitro Antioxidant and Antibacterial Activities

Synthesis, characterization, and applications of novel Co(II)‐pyridoxalphosphate‐Schiffbase/SBA‐15 as a nanocatalyst for the green synthesis of benzothiazole heterocycles

Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review

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