Synthesis and Anticancer Activity of Bis-(N-Glucosylated Triazolothiadiazolyl) Alkanes via Cyclocondensation Reaction Involving C–s and C–n Bond formation
“…A series of dicarboxylic acids such as tartaric, malic, 41-43 succinic, 44 glutaric, 45 and others 46 were treated with thiocarbohydrazide (5) to afford the respective series of bis-(4amino-5-mercapto[1,2,4]triazoles) 8, 9 (Scheme 2).…”
Section: Reactions With Carboxylic Acidsmentioning
4-Amino-5-mercapto[1,2,4]triazole and its 3-substituted derivatives have proven to be of biological interest and provide access to a new class of biologically active heterocyclic compounds for biomedical applications.
“…A series of dicarboxylic acids such as tartaric, malic, 41-43 succinic, 44 glutaric, 45 and others 46 were treated with thiocarbohydrazide (5) to afford the respective series of bis-(4amino-5-mercapto[1,2,4]triazoles) 8, 9 (Scheme 2).…”
Section: Reactions With Carboxylic Acidsmentioning
4-Amino-5-mercapto[1,2,4]triazole and its 3-substituted derivatives have proven to be of biological interest and provide access to a new class of biologically active heterocyclic compounds for biomedical applications.
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