Synthesis and Anticholinesterase Activity of N-Oxyalkyl-substituted Pyridinium and Hydroquinolinium Salts and Their Isologs

Abstract

N-oxyalkylpiperidines (perhydroquinolines), N-oxyalkylpyridinium (hydroquinolinium) salts, and oxazolo(oxazino)hydroquinolines obtained from 1,5-diketones and the products of their O-heterocyclization exhibit moderate anticholinesterase activity in comparison to that of galanthamine. The maximum inhibiting effect was observed for N-oxyalkylpyridinium salts.